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<p>Metal–organic frameworks (MOFs) have attracted significant interest in bone tissue engineering due to their ability to scavenge reactive oxygen species (ROS). MIL-88A, a member of the MOF nanozyme family, exhibits peroxidase-mimetic activity and good biocompatibility, making it a promising nano-enzyme repair system for promoting osteoarthritis healing. This study explores the role of MIL-88A particles embedded in porous scaffolds made from UV-curable soy-based commercial resin, printed using an Elegoo Saturn 3 printer. MIL-88A was synthesized using fumaric acid and FeCl<sub>3</sub>. The resulting composites were characterized using FTIR, XRD, and SEM techniques. Their bioactivity and biodegradability were evaluated <i>in-vitro</i> by immersion in simulated body fluid (SBF) and phosphate-buffered saline (PBS) for 9 and 28&#xa0;days and their behavior under compression was also evaluated. The results of morphological analysis, degradation resistance, and bioactivity suggest that the composites hold promise for use in tissue engineering applications.</p> Graphical abstract <p></p>

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Design of MOF/soja based-resin scaffolds by 3D resin printing technique

  • 期刊论文

  • 发表日期：

    2025年10月17日

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  • N. N. Zurita-Méndez,
  • G. Carbajal De la Torre,
  • I. Maldonado-Garcia,
  • M. A. Espinosa-Medina

摘要

Metal–organic frameworks (MOFs) have attracted significant interest in bone tissue engineering due to their ability to scavenge reactive oxygen species (ROS). MIL-88A, a member of the MOF nanozyme family, exhibits peroxidase-mimetic activity and good biocompatibility, making it a promising nano-enzyme repair system for promoting osteoarthritis healing. This study explores the role of MIL-88A particles embedded in porous scaffolds made from UV-curable soy-based commercial resin, printed using an Elegoo Saturn 3 printer. MIL-88A was synthesized using fumaric acid and FeCl3. The resulting composites were characterized using FTIR, XRD, and SEM techniques. Their bioactivity and biodegradability were evaluated in-vitro by immersion in simulated body fluid (SBF) and phosphate-buffered saline (PBS) for 9 and 28 days and their behavior under compression was also evaluated. The results of morphological analysis, degradation resistance, and bioactivity suggest that the composites hold promise for use in tissue engineering applications.

Graphical abstract