<p>Ti–Nb–Sn alloys are attractive for biomedical applications due to their low toxicity and favorable mechanical properties. This study evaluates the influence of a space-holder agent on Ti–Nb–Sn alloys fabricated by powder metallurgy. Alloys containing 0, 6, and 12 at.% Sn with 30% Nb and balance Ti were prepared, with and without ammonium carbonate as space-holder. Specimens were sintered and analyzed by SEM, EDS, and XRD; porosity, density, and Young’s modulus were measured, and corrosion resistance was assessed electrochemically. Results showed that the space-holder agent altered physical properties and reduced Young’s modulus to values closer to human bone, while corrosion potential remained mostly unaffected. The behavior suggests that the space-holder acts as a thermal buffer and promotes grain separation during sintering. In addition, the spacer agent reduces the sensitivity of the alloys to Sn content.</p> Graphical abstract <p></p>