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<p>In this study, hematite phase iron oxide (α-Fe₂O₃) nanoparticles were synthesized using ferric chloride hexahydrate and <i>Santalum album</i> extract via a green approach. Characterization using SEM, EDX, XRD, UV–Vis, FTIR, and VSM revealed nanoparticles with an average size of 43.1 ± 10&#xa0;nm and soft magnetic properties influenced by calcination temperatures (300–900&#xa0;℃). The nanoparticles demonstrated dose-dependent cytotoxicity against HepG2 liver cancer cells, with an IC<sub>50</sub> value of 52&#xa0;µg/mL. These findings highlight their potential for targeted cancer therapy. The green synthesis method offers an eco-friendly alternative for producing nanoparticles with biomedical applications.</p> Graphical Abstract <p></p>

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Green synthesis, characterization and in vitro anticancer activity of iron oxide nanoparticles (α-Fe2O3) derived from sandalwood (Santalum album) extract

  • 期刊论文

  • 发表日期：

    2025年6月25日

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  • Vandana Sharma,
  • J. K. Sharma,
  • Manoj Singh,
  • Anupam Sharma,
  • A. K. Sharma,
  • M. K. Bera

摘要

In this study, hematite phase iron oxide (α-Fe₂O₃) nanoparticles were synthesized using ferric chloride hexahydrate and Santalum album extract via a green approach. Characterization using SEM, EDX, XRD, UV–Vis, FTIR, and VSM revealed nanoparticles with an average size of 43.1 ± 10 nm and soft magnetic properties influenced by calcination temperatures (300–900 ℃). The nanoparticles demonstrated dose-dependent cytotoxicity against HepG2 liver cancer cells, with an IC50 value of 52 µg/mL. These findings highlight their potential for targeted cancer therapy. The green synthesis method offers an eco-friendly alternative for producing nanoparticles with biomedical applications.

Graphical Abstract