<p>Adsorption is the most used method to remove fluoride ions from water, being the adsorbent performance the key factor in the adsorption efficiency. Therefore, there is growing scientific interest in improving the characteristics of adsorbents for the remotion of contaminants. Although layered double hydroxides (LDH) have been widely investigated in the adsorption of fluoride ions, the influence of synthesis conditions of LDH and its effect on the removal of fluoride ions has been hardly explored. The aim of this work was to determine the influence of factors: molar ratio of the reactants and the crystals aging time of LDH synthesis on the fluoride adsorption. A factorial design of experiments <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\({3}^{2}\)</EquationSource> <EquationSource Format="MATHML"><math> <msup> <mrow> <mn>3</mn> </mrow> <mn>2</mn> </msup> </math></EquationSource> </InlineEquation>: molar ratio and aging time factors with three low, medium and high levels was executed. Results show a molar ratio of 4 and an aging time of 0&#xa0;h, in other words without aging as the best synthesis LDH conditions for fluoride removal (3.40&#xa0;mg/g). In addition, the most favorable conditions provide the less use of resources which is in line with Green Chemistry.</p> Graphical abstract <p></p>