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<p>Additive manufacturing processes are gaining popularity for the production of patient-specific biomedical devices as well as hospital supplies and equipment. For these applications, it is important that the materials are not prone to spreading infection. Herein, we examine how the fused filament fabrication process influences the morphology of surface grooves and how this affects bacterial adhesion and growth. We have measured the growth of <i>Escherichia coli</i> (<i>E. coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus)</i> on polylactic acid surfaces printed with differing infill geometries and layer heights. The results show that the adhesion and growth of <i>E. coli</i> was more sensitive to surface topography than <i>S. aureus</i>. There was a reduction in <i>E. coli</i> growth with samples that had an octogram spiral top infill and a 100-micron layer height. The findings of this research can be used to better understand how to manufacture objects with surfaces that inhibit microbial adhesion and growth.</p> Graphical abstract <p></p>

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Process-dependent control of bacterial adhesion and growth on additive manufacturing surfaces

  • 期刊论文

  • 发表日期：

    2025年2月3日

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  • Julianna Berger Harding,
  • Jabria L. Hooker,
  • Rustin J. Bellanger,
  • Angela M. Truxillo,
  • Wendy M. Schluchter,
  • Damon A. Smith

摘要

Additive manufacturing processes are gaining popularity for the production of patient-specific biomedical devices as well as hospital supplies and equipment. For these applications, it is important that the materials are not prone to spreading infection. Herein, we examine how the fused filament fabrication process influences the morphology of surface grooves and how this affects bacterial adhesion and growth. We have measured the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) on polylactic acid surfaces printed with differing infill geometries and layer heights. The results show that the adhesion and growth of E. coli was more sensitive to surface topography than S. aureus. There was a reduction in E. coli growth with samples that had an octogram spiral top infill and a 100-micron layer height. The findings of this research can be used to better understand how to manufacture objects with surfaces that inhibit microbial adhesion and growth.

Graphical abstract