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<p>Secondary flow enhancement in microfluidic chips offers a strategy for label-free particle and cell separation. Herein, digital light processing (DLP) is utilized to rapidly three-dimensional (3D) print microfluidic chips with different geometrical designs. Particle separation experiments are applied to systematically understand the effects of key channel geometric parameters and major flow conditions on the experimental recovery and large particle concentration in the given outlet. Additionally, numerical simulations are leveraged to explore the working mechanisms of the printed microfluidic chips, which are promising to serve as an efficient platform for cell separation in future.</p> Graphical abstract <p></p>

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Enhanced secondary flow-guided microfluidic chip design for cell separation

  • 期刊论文

  • 发表日期：

    2026年5月4日

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  • Lily Raymond,
  • Liam Bond,
  • Kellen Mitchell,
  • Ryan Coulter,
  • Pengbo Chu,
  • Na Xiao,
  • Yifei Jin

摘要

Secondary flow enhancement in microfluidic chips offers a strategy for label-free particle and cell separation. Herein, digital light processing (DLP) is utilized to rapidly three-dimensional (3D) print microfluidic chips with different geometrical designs. Particle separation experiments are applied to systematically understand the effects of key channel geometric parameters and major flow conditions on the experimental recovery and large particle concentration in the given outlet. Additionally, numerical simulations are leveraged to explore the working mechanisms of the printed microfluidic chips, which are promising to serve as an efficient platform for cell separation in future.

Graphical abstract