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Abstract <p>With the increasing demand for sustainable protein sources, cultured meat is attracting attention as an alternative to livestock. The anisotropic microarchitecture of meat, defined by aligned myofibers and intramuscular adipose tissue, influences sensory attributes, yet faithful recapitulation remains a major biofabrication challenge. Here, we applied the Filamented Light (FLight) technique to engineer 3D scaffolds featuring aligned microchannels (2–200&#xa0;µm) to direct adipose-derived stem cell orientation and adipogenic differentiation. Scaffolds with micrometer-scale channels promoted lipid accumulation and alignment while maintaining integrity. FLight offers a platform for reconstructing muscle–fat architectures in cultured meat.</p> Graphical abstract <p></p>

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Fabrication of aligned adipose tissues using the FLight method for cultured meat applications

  • 期刊论文

  • 发表日期：

    2025年12月29日

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  • Chika Nakadozono,
  • Hao Liu,
  • Marcy Zenobi-Wong,
  • Michiya Matsusaki

摘要

Abstract

With the increasing demand for sustainable protein sources, cultured meat is attracting attention as an alternative to livestock. The anisotropic microarchitecture of meat, defined by aligned myofibers and intramuscular adipose tissue, influences sensory attributes, yet faithful recapitulation remains a major biofabrication challenge. Here, we applied the Filamented Light (FLight) technique to engineer 3D scaffolds featuring aligned microchannels (2–200 µm) to direct adipose-derived stem cell orientation and adipogenic differentiation. Scaffolds with micrometer-scale channels promoted lipid accumulation and alignment while maintaining integrity. FLight offers a platform for reconstructing muscle–fat architectures in cultured meat.

Graphical abstract