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<p>In this work, Ta<sub>2</sub>O<sub>5</sub>-PAMAM-NH<sub>2</sub> dendrimer nanocomposite coatings are created by electrodeposition on titanium substrates with the goal of combining dual antibacterial activity and bioactive self-healing properties into a single, multipurpose platform. An apatite layer formed after 21&#xa0;days of immersion in simulated bodily fluid (SBF) at 36.5℃, demonstrating a robust interaction between the coating and the physiological medium in the <i>in vitro</i> bioactivity assessment. Computational investigations revealed strong intermolecular interactions between Ta<sub>2</sub>O<sub>5</sub> and PAMAM-NH<sub>2</sub> dendrimers, further improving system integrity, while thorough physico-chemical, electrochemical, morphological, and surface roughness characterizations confirmed the stability of the coating. Antibacterial tests verified the Ta<sub>2</sub>O<sub>5</sub>-PAMAM-NH<sub>2</sub> dendrimer nanocomposites exceptional resistance to bacterial adhesion without causing cytotoxicity, making it a viable next-generation coating for orthopedic implants.</p> Graphical abstract <p></p>

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Tantalum pentoxide-poly(amidoamine) dendrimer nanocomposite coatings: An approach to self-healing antibacterial properties for orthopedic implants

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Suja Mathai,
  • Priyanka S Shaji,
  • K S Sandhya

摘要

In this work, Ta2O5-PAMAM-NH2 dendrimer nanocomposite coatings are created by electrodeposition on titanium substrates with the goal of combining dual antibacterial activity and bioactive self-healing properties into a single, multipurpose platform. An apatite layer formed after 21 days of immersion in simulated bodily fluid (SBF) at 36.5℃, demonstrating a robust interaction between the coating and the physiological medium in the in vitro bioactivity assessment. Computational investigations revealed strong intermolecular interactions between Ta2O5 and PAMAM-NH2 dendrimers, further improving system integrity, while thorough physico-chemical, electrochemical, morphological, and surface roughness characterizations confirmed the stability of the coating. Antibacterial tests verified the Ta2O5-PAMAM-NH2 dendrimer nanocomposites exceptional resistance to bacterial adhesion without causing cytotoxicity, making it a viable next-generation coating for orthopedic implants.

Graphical abstract