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<p>Grafting is an approach that allows new functional groups to be added to polymeric matrices, improving physicochemical properties. This investigation focused on binary grafting of N-Vinylcaprolactam (NVCL) and hydroxyethyl methacrylate (HEMA) onto silicone catheters (SR) by using gamma-ray irradiation at a dose rate of 12.8&#xa0;kGy&#xa0;h<sup>−1</sup>, doses ranging from 20 to 80&#xa0;kGy, and monomer concentrations of 50 and 25% (<i>w/v</i>). The conditions with the highest grafting percentage were 60&#xa0;kGy and 25% monomer. The grafted silicone catheters were characterized by contact angle, infrared, swelling, and TGA. The modification of silicones enabled the loading of ciprofloxacin.</p> Graphical abstract <p></p>

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Functionalization of silicone catheters by grafting hydroxyethyl methacrylate and N‑vinylcaprolactam using gamma radiation for drug loading and release studies

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • Miguel S. Pérez-Garibay,
  • Alejandro Camacho-Cruz,
  • Emilio Bucio

摘要

Grafting is an approach that allows new functional groups to be added to polymeric matrices, improving physicochemical properties. This investigation focused on binary grafting of N-Vinylcaprolactam (NVCL) and hydroxyethyl methacrylate (HEMA) onto silicone catheters (SR) by using gamma-ray irradiation at a dose rate of 12.8 kGy h−1, doses ranging from 20 to 80 kGy, and monomer concentrations of 50 and 25% (w/v). The conditions with the highest grafting percentage were 60 kGy and 25% monomer. The grafted silicone catheters were characterized by contact angle, infrared, swelling, and TGA. The modification of silicones enabled the loading of ciprofloxacin.

Graphical abstract