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<p>Calcium phosphate cement (CPC) shows great clinical potential, and its properties can be improved by additives and process optimization. In this study, CPCs doped with tetracalcium phosphate (TTCP) were prepared. High-crystallinity TTCP (HTTCP) enhanced CPC’s compressive strength, reduced porosity, and promoted needle-like hydroxyapatite (HA) formation. However, the compression strength showed a trend of first increasing and then decreasing, peaking at 5 wt.% HTTCP. In simulated body fluid, 5 wt.% HTTCP-doped CPC transitioned from initial dissolution to precipitation, forming nanoneedle HA, confirming its excellent bioactivity for bone repair.</p> Graphical Abstract <p></p>

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Microstructure and properties of calcium phosphate cement modified with high crystalline tetracalcium phosphate

  • 期刊论文

  • 发表日期：

    2025年10月6日

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  • Diangang Wang,
  • Xiangyue Ji,
  • Jiankai Wang,
  • Zhong Chen,
  • Huancai Li,
  • Chuanzhong Chen

摘要

Calcium phosphate cement (CPC) shows great clinical potential, and its properties can be improved by additives and process optimization. In this study, CPCs doped with tetracalcium phosphate (TTCP) were prepared. High-crystallinity TTCP (HTTCP) enhanced CPC’s compressive strength, reduced porosity, and promoted needle-like hydroxyapatite (HA) formation. However, the compression strength showed a trend of first increasing and then decreasing, peaking at 5 wt.% HTTCP. In simulated body fluid, 5 wt.% HTTCP-doped CPC transitioned from initial dissolution to precipitation, forming nanoneedle HA, confirming its excellent bioactivity for bone repair.

Graphical Abstract