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<p><i>In vivo</i> microvascular imaging provides a more comprehensive understanding of microvascular function and its role in disease progression, particularly in cancer metastasis. We previously developed gadolinium chelates and fluorescein-conjugated polyethylene glycol as supramolecular contrast agents for magnetic resonance imaging. Here, we evaluated the effect of fluorescein labeling ratio on the stability of the complex. Furthermore, we imaged microvessels inside the cancer tissue using the supramolecular contrast agent in a rat subcutaneous tumor model and demonstrated for the first time that the tumor size and number of blood vessels correlated with imaging data.</p> Graphical Abstract <p></p>

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In vivo microvascular imaging in subcutaneous tumor by fluorescein-induced supramolecular contrast agents for magnetic resonance imaging

  • 期刊论文

  • 发表日期：

    2025年9月30日

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  • Xin Tian,
  • Raghav Soni,
  • Natsuo Banura,
  • Shigeyoshi Saito,
  • Haiqing Yang,
  • Atsushi Mahara

摘要

In vivo microvascular imaging provides a more comprehensive understanding of microvascular function and its role in disease progression, particularly in cancer metastasis. We previously developed gadolinium chelates and fluorescein-conjugated polyethylene glycol as supramolecular contrast agents for magnetic resonance imaging. Here, we evaluated the effect of fluorescein labeling ratio on the stability of the complex. Furthermore, we imaged microvessels inside the cancer tissue using the supramolecular contrast agent in a rat subcutaneous tumor model and demonstrated for the first time that the tumor size and number of blood vessels correlated with imaging data.

Graphical Abstract