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<p>Highly organized extracellular matrix (ECM) with embedded apatite inherits significant piezoelectric behaviur in skeletal tissue. Herein, demineralized fish scale matrix (DFM) is explored as stimuli-responsive biotemplate. Polyvinylidene Fluoride (PVDF)-based aligned nanofabric integrated with collagen-rich DFM was explored as multi-layered bio-template to tailor electrical stimuli under dynamic load. Electrospun aligned β-PVDF significantly improved electro-mechanical stimuli. Different physico-chemical analysis including Small-angle X-ray scattering (SAXS) evidenced matrix morphology with anisotropic scattering pattern. Cyclic voltammetry and conductivity measurement further demonstrated piezoelectric behaviur under mechanical stimuli. Thus, bioactive piezo-responsive matrix could be integrated <i>in vivo</i> as biotemplate towards stimuli-responsive tissue regeneration application.</p> Graphical abstract <p></p>

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Ethically sourced biotemplate engineered with smart polymer for promoting skeletal tissue regeneration

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • Santanu Dhara,
  • Sri Medha Juloori,
  • Samir Das,
  • Partha Sarathi Mandal,
  • Manish Pal Chowdhury

摘要

Highly organized extracellular matrix (ECM) with embedded apatite inherits significant piezoelectric behaviur in skeletal tissue. Herein, demineralized fish scale matrix (DFM) is explored as stimuli-responsive biotemplate. Polyvinylidene Fluoride (PVDF)-based aligned nanofabric integrated with collagen-rich DFM was explored as multi-layered bio-template to tailor electrical stimuli under dynamic load. Electrospun aligned β-PVDF significantly improved electro-mechanical stimuli. Different physico-chemical analysis including Small-angle X-ray scattering (SAXS) evidenced matrix morphology with anisotropic scattering pattern. Cyclic voltammetry and conductivity measurement further demonstrated piezoelectric behaviur under mechanical stimuli. Thus, bioactive piezo-responsive matrix could be integrated in vivo as biotemplate towards stimuli-responsive tissue regeneration application.

Graphical abstract