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<p>Contrast-enhancing agents are commonplace in medical X-ray Computed Tomography. However, their use in laboratory-scale micro–X-ray Computed Tomography (µXCT) for morphological measurements of tissue-like or tissue-scaffold applications (e.g., 3D-printed artificial organs) is limited. We demonstrate enhanced contrast and enable print quality measurement with µXCT <i>via</i> a colloidal suspension of nano-silica spheres (c-SiO<sub>2</sub>). Contrast is enhanced by the higher attenuation coefficient of the silica than hydrogel, which provides for 3D image analysis. We tested several c-SiO<sub>2</sub> dilutions and found an optimal selection that balances viscosity and contrast. We further demonstrate the technique by measuring a prototype dialyzer-like device.</p> Graphical abstract <p></p>

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A method to use X-ray computed tomography for measuring perfusable, high-resolution 3D-printed hydrogel structures

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月22日

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  • Orion L. Kafka,
  • Thomas J. Kolibaba,
  • Rion J. Wendland,
  • Callie I. Higgins,
  • Grant Draper,
  • Nick Clinton,
  • Raghuveer Lalitha Sridhar,
  • Kalyan Vydiam,
  • Daniel Backman,
  • Aman Kaur,
  • Matt Gelber,
  • Matthew Bedell,
  • Scott Turner,
  • Jason P. Killgore

摘要

Contrast-enhancing agents are commonplace in medical X-ray Computed Tomography. However, their use in laboratory-scale micro–X-ray Computed Tomography (µXCT) for morphological measurements of tissue-like or tissue-scaffold applications (e.g., 3D-printed artificial organs) is limited. We demonstrate enhanced contrast and enable print quality measurement with µXCT via a colloidal suspension of nano-silica spheres (c-SiO2). Contrast is enhanced by the higher attenuation coefficient of the silica than hydrogel, which provides for 3D image analysis. We tested several c-SiO2 dilutions and found an optimal selection that balances viscosity and contrast. We further demonstrate the technique by measuring a prototype dialyzer-like device.

Graphical abstract