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<p>Nanomaterials are actively being exploited for different theranostic and&#xa0;nanomedicine applications. Central to effective and safe&#xa0;applications of these nanomaterials are their selective targeting and delivery into specific subcellular organelles. Herein, we discuss various surface engineering strategies to enhance the intracellular delivery of theranostic&#xa0;nanomaterials. We will first provide a broad overview of the different types of nanomaterials explored for intracellular targeting. Next, we will describe numerous established and emerging approaches to surface engineer theranostic&#xa0;nanomaterials to enhance their cellular uptake and intracellular trafficking and localization. We will finally conclude this Prospective by offering our outlook on the current challenges and future opportunities in this field.</p> Graphical abstract <p></p>

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Surface engineering of theranostic nanomaterials for intracellular trafficking and localization

  • 期刊论文

  • 发表日期：

    2025年8月4日

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  • Célia Sahli,
  • Tiffany Thanhtruc Pham,
  • Sienna Sky Madriaga,
  • Sophia Buttny,
  • Amelia Luadtke,
  • Kenry

摘要

Nanomaterials are actively being exploited for different theranostic and nanomedicine applications. Central to effective and safe applications of these nanomaterials are their selective targeting and delivery into specific subcellular organelles. Herein, we discuss various surface engineering strategies to enhance the intracellular delivery of theranostic nanomaterials. We will first provide a broad overview of the different types of nanomaterials explored for intracellular targeting. Next, we will describe numerous established and emerging approaches to surface engineer theranostic nanomaterials to enhance their cellular uptake and intracellular trafficking and localization. We will finally conclude this Prospective by offering our outlook on the current challenges and future opportunities in this field.

Graphical abstract