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<p>Alpha lipoic acid (ALA) is a potent antioxidant with anti-inflammatory and antifibrotic effects. However, ALA is susceptible to degradation, limited solubility, and low bioavailability. In this study, we evaluated ALA in its free form versus ALA released from hybrid nanoparticles (NPLs) composed of poly(lactic-co-glycolic acid) and soybean L-alpha-phosphatidylcholine in an <i>in vitro</i> model of metabolic dysfunction-associated steatohepatitis (MASH). Human hepatic stellate cells from a MASH patient treated with NPLs-ALA showed a significant reduction in the expression of profibrotic genes compared to cells treated with free ALA, which highlights NPLs-ALA as a potential therapeutic for MASH.</p> Graphical abstract <p></p>

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Incorporation of alpha lipoic acid into polymer-lipid nanoparticles enhances its antifibrotic activity in an in vitro model using human hepatic stellate cells

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Kevin D. Martínez-García,
  • Gabriela I. Carballo-López,
  • Marco A. Uriostegui-Campos,
  • Johanna Bernáldez-Sarabia,
  • Ana B. Castro-Ceseña

摘要

Alpha lipoic acid (ALA) is a potent antioxidant with anti-inflammatory and antifibrotic effects. However, ALA is susceptible to degradation, limited solubility, and low bioavailability. In this study, we evaluated ALA in its free form versus ALA released from hybrid nanoparticles (NPLs) composed of poly(lactic-co-glycolic acid) and soybean L-alpha-phosphatidylcholine in an in vitro model of metabolic dysfunction-associated steatohepatitis (MASH). Human hepatic stellate cells from a MASH patient treated with NPLs-ALA showed a significant reduction in the expression of profibrotic genes compared to cells treated with free ALA, which highlights NPLs-ALA as a potential therapeutic for MASH.

Graphical abstract