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Abstract <p>In the field of bone tissue engineering, 3D macro-porous scaffolds with bioactive surfaces are garnering attention as innovative integral matrices that support cell proliferation, differentiation, and tissue development. In this study, we designed 3D composite scaffolds of reduced graphene oxide, polypyrrole, and titanium dioxide (rGO/PPY/TiO<sub>2</sub>) through a seed-assisted hydrothermal method. The as-prepared scaffold exhibits excellent biocompatibility and significantly enhances the growth of human bone marrow mesenchymal stem cells (HMSCs), surpassing the performance of the 3D rGO/PPY scaffold. Additionally, it demonstrates superior antibacterial properties. Furthermore, alkaline phosphatase activity tests and alizarin red S&#xa0;staining results indicate that this scaffold significantly promotes the osteogenic differentiation, underscoring its substantial potential for application in bone tissue engineering.</p> Graphical abstract <p>In bone tissue engineering, 3D macro-porous scaffolds with bioactive surfaces are garnering attention as innovative integral matrices for cell proliferation, differentiation, and tissue formation. In this study, we designed 3D reduced graphene oxide/polypyrrole/titanium dioxide (rGO/PPY/TiO<sub>2</sub>) composite scaffolds through a seed-assisted hydrothermal method. The as-prepared scaffold exhibits excellent biocompatibility and significantly enhances the proliferation of human bone marrow mesenchymal stem cell, outperforming the 3D rGO/PPY scaffold. Additionally, it demonstrates superior antibacterial properties. Furthermore, alkaline phosphatase activity tests and alizarin red S&#xa0;staining results indicate that this scaffold significantly promotes the osteogenic differentiation, underscoring its substantial potential for application in bone tissue engineering.</p> <p></p>

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Facile fabrication of three-dimensional rGO/PPY/TiO2 composite scaffolds with superior antibacterial properties and promoting proliferation

  • 期刊论文

  • 发表日期：

    2025年1月17日

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  • Xiaoxue Mai,
  • Tiandi Chen,
  • Feng Wang,
  • Weibo Xie

摘要

Abstract

In the field of bone tissue engineering, 3D macro-porous scaffolds with bioactive surfaces are garnering attention as innovative integral matrices that support cell proliferation, differentiation, and tissue development. In this study, we designed 3D composite scaffolds of reduced graphene oxide, polypyrrole, and titanium dioxide (rGO/PPY/TiO2) through a seed-assisted hydrothermal method. The as-prepared scaffold exhibits excellent biocompatibility and significantly enhances the growth of human bone marrow mesenchymal stem cells (HMSCs), surpassing the performance of the 3D rGO/PPY scaffold. Additionally, it demonstrates superior antibacterial properties. Furthermore, alkaline phosphatase activity tests and alizarin red S staining results indicate that this scaffold significantly promotes the osteogenic differentiation, underscoring its substantial potential for application in bone tissue engineering.

Graphical abstract

In bone tissue engineering, 3D macro-porous scaffolds with bioactive surfaces are garnering attention as innovative integral matrices for cell proliferation, differentiation, and tissue formation. In this study, we designed 3D reduced graphene oxide/polypyrrole/titanium dioxide (rGO/PPY/TiO2) composite scaffolds through a seed-assisted hydrothermal method. The as-prepared scaffold exhibits excellent biocompatibility and significantly enhances the proliferation of human bone marrow mesenchymal stem cell, outperforming the 3D rGO/PPY scaffold. Additionally, it demonstrates superior antibacterial properties. Furthermore, alkaline phosphatase activity tests and alizarin red S staining results indicate that this scaffold significantly promotes the osteogenic differentiation, underscoring its substantial potential for application in bone tissue engineering.