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<p>Pelvic organ prolapse, caused by weakened structural support, is often treated with surgical interventions such as suturing, native tissue repair, or transvaginal mesh (TVM). However, suture and tissue repair have high recurrence rates, and TVM can lead to complications like erosion and organ perforation. This study developed a biocompatible TVM incorporating iodine-conjugated carbon dots for non-invasive <i>in situ</i> imaging <i>via</i> medical imaging. The mesh mimics native tissue properties, potentially reducing pain, inflammation, and toxicity while enhancing compatibility. This innovation addresses complications of current TVMs, offering a promising alternative to improve outcomes for pelvic organ prolapse repair.</p> Graphical abstract <p></p>

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Advanced visible surgical scaffold to enhance urogynaecological health

  • 期刊论文

  • 发表日期：

    2025年1月6日

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  • Chaya Tiktin,
  • Rumbidzai Zizhou,
  • Elena Pirogova,
  • Shadi Houshyar

摘要

Pelvic organ prolapse, caused by weakened structural support, is often treated with surgical interventions such as suturing, native tissue repair, or transvaginal mesh (TVM). However, suture and tissue repair have high recurrence rates, and TVM can lead to complications like erosion and organ perforation. This study developed a biocompatible TVM incorporating iodine-conjugated carbon dots for non-invasive in situ imaging via medical imaging. The mesh mimics native tissue properties, potentially reducing pain, inflammation, and toxicity while enhancing compatibility. This innovation addresses complications of current TVMs, offering a promising alternative to improve outcomes for pelvic organ prolapse repair.

Graphical abstract