Fast microwave-assisted methacrylation of Pluronics for photoinduced 3D printing

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发表日期：

2024年8月6日

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Mateus P. Bomediano,
Murilo I. Santos,
Marcos V. Lorevice,
Giovana B. Romano,
Laura C. E. da Silva,
Airton G. S. Junior,
Marcelo G. de Oliveira

摘要

Methacrylation of Pluronics enables 3D printing of irreversible hydrogel constructs, thereby diversifying their potential applications. Current methods rely on organic solvents and time-consuming reactions. Herein, a rapid method for the microwave-assisted methacrylation of Pluronics by methacrylic anhydride (MA) in the absence of organic solvents is presented, which reduced the reaction time from 24 h to ca. 10 min. ¹H-NMR analysis showed that this method allows modulating the methacrylation degree (MD) of Pluronics from 45 to 97% by using different MA:Pluronic ratios. 3D-printed constructs with lower MD showed larger pores and lower compression modulus.

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