Temporally controlling the release of biofactors from polymeric microspheres

To improve the integrity of tendons, mitigating scar tissue formation by targeting the cellular activities that contribute to fibrosis during healing is crucial. Microparticles are a promising solution by delivering biofactors directly to the injury site. We synthesized poly (lactic-co-glycolic acid) microspheres with Labrafil oil to control the release profile. The release of biofactors was initially delayed, followed by an increased release rate. Thus, by increasing the hydrophobicity of the polymer, Labrafil oil delays microsphere degradation and ultimately controls the release of an encapsulated factor. Further, the system can be utilized for multi-factorial release to temporally complement tendon healing.