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<p>Despite the experimentally proven possibility of bioconjugation of cadmium-containing quantum dots with proteins, the physical mechanisms of formation and stability of bionanocomplexes remain unclear. In work, a thermodynamic analysis of the interaction between CdTe quantum dots and protein was performed. A model of the quantum dot–protein bionanocomplex was developed based on the method of self-consistent electron-deformation coupling, and a toxicological assessment was conducted using <i>Drosophila melanogaster</i> as a model object at all stages of ontogenesis. It was found that the quenching of albumin fluorescence is static, indicating the formation of a stable complex. Analysis revealed that the electron-deformation interaction plays a major role in the formation and stabilization of the CdTe–protein bionanocomplex. In the group of flies treated with CdTe, the percentage of their offspring fledging decreased to 53%. In the group treated with CdTe quantum dot–protein complexes, the offspring hatching rate was 96%.</p> Graphical abstract <p></p>

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Modeling bioconjugation of cadmium-containing semiconductor quantum dots with proteins

  • 期刊论文

  • 发表日期：

    2026年5月18日

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  • Oleh Kuzyk,
  • Andriy Stolyarchuk,
  • Olesya Dan’kiv,
  • Ihor Stolyarchuk,
  • Halyna Klepach,
  • Natalia Holub

摘要

Despite the experimentally proven possibility of bioconjugation of cadmium-containing quantum dots with proteins, the physical mechanisms of formation and stability of bionanocomplexes remain unclear. In work, a thermodynamic analysis of the interaction between CdTe quantum dots and protein was performed. A model of the quantum dot–protein bionanocomplex was developed based on the method of self-consistent electron-deformation coupling, and a toxicological assessment was conducted using Drosophila melanogaster as a model object at all stages of ontogenesis. It was found that the quenching of albumin fluorescence is static, indicating the formation of a stable complex. Analysis revealed that the electron-deformation interaction plays a major role in the formation and stabilization of the CdTe–protein bionanocomplex. In the group of flies treated with CdTe, the percentage of their offspring fledging decreased to 53%. In the group treated with CdTe quantum dot–protein complexes, the offspring hatching rate was 96%.

Graphical abstract