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Abstract <p>In this study, polyvinyl alcohol (PVA) nanofiber dressings were obtained by electrospinning for use as drug delivery systems for gentamicin sulfate (GEN) and diclofenac sodium (SD) to treat pain, inflammation, and infection in skin lesions. The PVA–GEN/SD dressings were processed following a 2<sup>5-2</sup> fractional experimental design, and the average nanofiber diameter was evaluated as a response. Scanning electron microscopy (SEM) revealed nanofibers with different morphologies, with diameters ranging from 80 to 215&#xa0;nm. Fourier transform infrared spectroscopy (FTIR) was used to verify the incorporation of GEN and SD into the PVA–GEN/SD dressing, respectively. In inhibition zone assays, the antimicrobial activity of GEN on the nanofibers was found to be superior to that obtained with the free drug, requiring four times less antibiotic in the nanofibers to achieve similar inhibitory behavior. The drug content in the nanofibers results in 100% capture efficiency for both drugs.</p> Graphical abstract <p></p>

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Gentamicin sulfate and sodium diclofenac loaded in PVA nanofiber dressings for transdermal drug delivery

  • 期刊论文

  • 发表日期：

    2026年1月26日

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  • Ningel Omar Gama Castañeda,
  • Rocio Guadalupe Casañas Pimentel,
  • Julieta Luna Herrera,
  • Margarita Franco Colín,
  • Eduardo San Martin Martinez

摘要

Abstract

In this study, polyvinyl alcohol (PVA) nanofiber dressings were obtained by electrospinning for use as drug delivery systems for gentamicin sulfate (GEN) and diclofenac sodium (SD) to treat pain, inflammation, and infection in skin lesions. The PVA–GEN/SD dressings were processed following a 25-2 fractional experimental design, and the average nanofiber diameter was evaluated as a response. Scanning electron microscopy (SEM) revealed nanofibers with different morphologies, with diameters ranging from 80 to 215 nm. Fourier transform infrared spectroscopy (FTIR) was used to verify the incorporation of GEN and SD into the PVA–GEN/SD dressing, respectively. In inhibition zone assays, the antimicrobial activity of GEN on the nanofibers was found to be superior to that obtained with the free drug, requiring four times less antibiotic in the nanofibers to achieve similar inhibitory behavior. The drug content in the nanofibers results in 100% capture efficiency for both drugs.

Graphical abstract