Scholarlink

<p>Hydroxyapatite (HA) has good biocompatibility, but its brittleness restricts its application in the biomedical field. In this paper, three types of iron-based HA biocomposites were prepared with powder metallurgy: Fe/HA (Fe73), Fe30Mn6Si/HA (Si73), and Fe25Mn10Cu/HA (Cu73). The microstructure, mechanical properties, degradation performance, and biocompatibility of three samples was systematically studied. The results showed that Si73 composite material exhibits unique comprehensive advantages: its degradation rate (weight loss rate of 60.618%) is highly matched with the bone tissue regeneration cycle, and its moderate mechanical properties (lower hardness of 75Hv and compressive strength of 36.35&#xa0;MPa) are closer to human bone. Moreover, it showed excellent biocompatibility, with a cell proliferation rate (relative growth rate, RGR) reaching 114% at 12.5% extract concentration, indicating no cytotoxicity. The introduction of Mn, Si, and Cu elements has reconstructed the performance boundary of iron-based HA composite materials from three aspects: mechanical properties, electrochemical activity, and biocompatibility.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biomechanical properties of HA composites of different Fe alloys in orthopedics

  • 期刊论文

  • 发表日期：

    2025年12月2日

查看全文
  • Siqi Zhao,
  • Shuwen Chen,
  • Nan Huang,
  • Yingxue Teng

摘要

Hydroxyapatite (HA) has good biocompatibility, but its brittleness restricts its application in the biomedical field. In this paper, three types of iron-based HA biocomposites were prepared with powder metallurgy: Fe/HA (Fe73), Fe30Mn6Si/HA (Si73), and Fe25Mn10Cu/HA (Cu73). The microstructure, mechanical properties, degradation performance, and biocompatibility of three samples was systematically studied. The results showed that Si73 composite material exhibits unique comprehensive advantages: its degradation rate (weight loss rate of 60.618%) is highly matched with the bone tissue regeneration cycle, and its moderate mechanical properties (lower hardness of 75Hv and compressive strength of 36.35 MPa) are closer to human bone. Moreover, it showed excellent biocompatibility, with a cell proliferation rate (relative growth rate, RGR) reaching 114% at 12.5% extract concentration, indicating no cytotoxicity. The introduction of Mn, Si, and Cu elements has reconstructed the performance boundary of iron-based HA composite materials from three aspects: mechanical properties, electrochemical activity, and biocompatibility.

Graphical Abstract