Scholarlink

<p>Polyurethanes are versatile polymers that are frequently utilized in biomedical devices. To improve biocompatibility and antibacterial performance for the development of cardiovascular devices, we present in this study the novel synthesis of polyurethanes modified with chitosan grafted with gallic acid. Using castor oil and isophorone diisocyanate, the prepolymer method was used to create the polyurethanes. Heparin (0.05 and 0.1 weight percent) and chitosan-gallic acid conjugates (1, 2, and 3 weight percent) were also added. Tensile testing, DSC, and TGA were used to assess mechanical and thermal properties, While FTIR and SEM were used for structural and surface characterizations. The materials interacted favorably with l-929 fibroblast cells and demonstrated enhanced mechanical resistance and thermal stability. Furthermore, hemocompatibility tests and antibacterial assays against <i>Escherichia coli</i> and MRSA validated their potential for biomaterials. One promising method for creating next-generation polyurethanes with improved biological functionality for cardiovascular applications is functionalization using gallic acid-grafted chitosan.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biocompatibility, mechanical, thermal, and physicochemical properties of heparin/chitosan-gallic acid-crosslinked polyurethanes for cardiovascular device design

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月24日

查看全文
  • Yomaira Lisnedy Uscátegui Maldonado,
  • Luis Eduardo Díaz Barrera,
  • Manuel F. Valero,
  • Ericsson David Coy-Barrera

摘要

Polyurethanes are versatile polymers that are frequently utilized in biomedical devices. To improve biocompatibility and antibacterial performance for the development of cardiovascular devices, we present in this study the novel synthesis of polyurethanes modified with chitosan grafted with gallic acid. Using castor oil and isophorone diisocyanate, the prepolymer method was used to create the polyurethanes. Heparin (0.05 and 0.1 weight percent) and chitosan-gallic acid conjugates (1, 2, and 3 weight percent) were also added. Tensile testing, DSC, and TGA were used to assess mechanical and thermal properties, While FTIR and SEM were used for structural and surface characterizations. The materials interacted favorably with l-929 fibroblast cells and demonstrated enhanced mechanical resistance and thermal stability. Furthermore, hemocompatibility tests and antibacterial assays against Escherichia coli and MRSA validated their potential for biomaterials. One promising method for creating next-generation polyurethanes with improved biological functionality for cardiovascular applications is functionalization using gallic acid-grafted chitosan.

Graphical abstract