Scholarlink

<p>In this study, Ni, Cu, and Zn-based metal–organic frameworks (MOFs) were synthesized and characterized, followed by biological evaluation against selected bacterial and fungal strains. Minimum Inhibitory Concentration study results highlighted the superior antimicrobial efficiency of Cu-MOF with as low as MIC values of 128&#xa0;µg/ml against the bacterial strains of <i>Escherichia coli</i> (<i>E. coli)</i> and Staphylococcus aureus (<i>S. aureus)</i>. To study synergistic effect of the most potential candidate Cu-MOF with the proven antibiotic ciprofloxacin. The interaction and synergistic effect between the Cu-MOF and ciprofloxacin was confirmed by the Fractional inhibitory concentration index (FICI) values of 0.37 and 0.31 against the <i>S. aureus and E. coli</i> bacterial strains and the low amount needed of Cu-MOF 16&#xa0;µg/ml and 8&#xa0;µg/ml with the combination of 1&#xa0;µg/ml and 0.5&#xa0;µg/ml of the ciprofloxacin respectively. These findings advocate the broader applications of synergistic strategies and novel approaches in biomedical materials to the fight against bacterial infections.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synergistic interaction of copper MOF and ciprofloxacin for enhanced antibacterial activity: A novel approach in biomedical materials and drug design strategy

  • 期刊论文

  • 发表日期：

    2025年9月4日

查看全文
  • Prachi Prachi,
  • Asghar Ali,
  • Mohammad Abid,
  • Mohan Kamthan,
  • Chhaya Ravi Kant

摘要

In this study, Ni, Cu, and Zn-based metal–organic frameworks (MOFs) were synthesized and characterized, followed by biological evaluation against selected bacterial and fungal strains. Minimum Inhibitory Concentration study results highlighted the superior antimicrobial efficiency of Cu-MOF with as low as MIC values of 128 µg/ml against the bacterial strains of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). To study synergistic effect of the most potential candidate Cu-MOF with the proven antibiotic ciprofloxacin. The interaction and synergistic effect between the Cu-MOF and ciprofloxacin was confirmed by the Fractional inhibitory concentration index (FICI) values of 0.37 and 0.31 against the S. aureus and E. coli bacterial strains and the low amount needed of Cu-MOF 16 µg/ml and 8 µg/ml with the combination of 1 µg/ml and 0.5 µg/ml of the ciprofloxacin respectively. These findings advocate the broader applications of synergistic strategies and novel approaches in biomedical materials to the fight against bacterial infections.

Graphical abstract