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<p>Sepsis is the primary cause of death in those with severe illness. However, there is no targeted therapy for sepsis, and its successful care depends on infection control measures. This study achieved a new nanodrug with anti-inflammatory and antibacterial properties by incorporating ceftazidime (CFZ) into ZIF-8. The fabricated zeolitic imidazolate framework-8 (ZIF-8)-incorporated CFZ (CFZ@ZIF-8) nanocomposites (NCs) were evaluated by analyzing variations in size and functional groups. Significantly, the CFZ@ZIF-8 provided the nanocomposites with anti-inflammatory properties through its antioxidant ability to induce macrophage polarization. Furthermore, the fabricated CFZ@ZIF-8 NCs showed potent antibacterial action against <i>Staphylococcus aureus</i> (22.8% CFU/mL) and <i>Escherichia coli</i> (32.5% CFU/mL) and reduced the duration of sepsis treatment and the inflammation. Moreover, CFZ@ZIF-8 NCs exhibited suitable cytocompatibility (99% in 60&#xa0;µg/mL). Therefore, CFZ@ZIF-8 NCs have the potential to be superior as a versatile nanomedicine with anti-inflammatory and bactericidal features, hence improving the nursing care management of sepsis.</p> Graphical abstract <p></p>

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Fabrication of ceftazidime antibiotic-incorporated zeolitic imidazolate framework-8 captivating endotoxins and proinflammatory cytokines in potential sepsis therapy

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Lanping He,
  • Zide Wang,
  • Yulan Zheng,
  • Hong Pu

摘要

Sepsis is the primary cause of death in those with severe illness. However, there is no targeted therapy for sepsis, and its successful care depends on infection control measures. This study achieved a new nanodrug with anti-inflammatory and antibacterial properties by incorporating ceftazidime (CFZ) into ZIF-8. The fabricated zeolitic imidazolate framework-8 (ZIF-8)-incorporated CFZ (CFZ@ZIF-8) nanocomposites (NCs) were evaluated by analyzing variations in size and functional groups. Significantly, the CFZ@ZIF-8 provided the nanocomposites with anti-inflammatory properties through its antioxidant ability to induce macrophage polarization. Furthermore, the fabricated CFZ@ZIF-8 NCs showed potent antibacterial action against Staphylococcus aureus (22.8% CFU/mL) and Escherichia coli (32.5% CFU/mL) and reduced the duration of sepsis treatment and the inflammation. Moreover, CFZ@ZIF-8 NCs exhibited suitable cytocompatibility (99% in 60 µg/mL). Therefore, CFZ@ZIF-8 NCs have the potential to be superior as a versatile nanomedicine with anti-inflammatory and bactericidal features, hence improving the nursing care management of sepsis.

Graphical abstract