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<p>A multifunctional catechin-encapsulated PLGA/chitosan nanofiber was fabricated using a simple electrospinning technique and an antimicrobial agent for wound healing applications. Incorporating catechin into the PLGA/chitosan matrix enhanced the thermal stability and pH-responsive drug release efficacy. CA@PLGA/CS nanofibers show almost 65% of catechin was released over 48&#xa0;h. The antibacterial experiments confirmed that the CA@PLGA/CS nanofibers effectively reduced bacterial colonies. The MIC (IC<sub>50</sub>) values of pathogens were found to be 45.13 ± 1.02&#xa0;μg/mL for <i>S. aureus</i> and 50.40 ± 1.03&#xa0;μg/mL for <i>E. coli</i>. Antifungal assays indicated that the fabricated CA@PLGA/CS nanofibers inhibited against <i>A. fumigatus</i> and <i>C. albicans</i>. The nanofibers demonstrated immediate cell regeneration and migration in fibroblast cells. Cytotoxicity studies confirmed that the CA@PLGA/CS nanofibers are biocompatible in non-cancerous cells. This investigation demonstrates that CA@PLGA/CS nanofibers matrix enhances the biomedical functionality of CA@PLGA/CS nanofibers, making them promising materials for infected wound healing and nursing care applications.</p> Graphical abstract <p></p>

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Facile fabrication of catechin-loaded PLGA/chitosan nanofibers for effective nursing care of wound-infecting bacterial pathogens and healing

  • 期刊论文

  • 发表日期：

    2025年5月28日

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  • Fei Xu,
  • Jielin Zhang,
  • Helin Wang,
  • Linli Jiang

摘要

A multifunctional catechin-encapsulated PLGA/chitosan nanofiber was fabricated using a simple electrospinning technique and an antimicrobial agent for wound healing applications. Incorporating catechin into the PLGA/chitosan matrix enhanced the thermal stability and pH-responsive drug release efficacy. CA@PLGA/CS nanofibers show almost 65% of catechin was released over 48 h. The antibacterial experiments confirmed that the CA@PLGA/CS nanofibers effectively reduced bacterial colonies. The MIC (IC50) values of pathogens were found to be 45.13 ± 1.02 μg/mL for S. aureus and 50.40 ± 1.03 μg/mL for E. coli. Antifungal assays indicated that the fabricated CA@PLGA/CS nanofibers inhibited against A. fumigatus and C. albicans. The nanofibers demonstrated immediate cell regeneration and migration in fibroblast cells. Cytotoxicity studies confirmed that the CA@PLGA/CS nanofibers are biocompatible in non-cancerous cells. This investigation demonstrates that CA@PLGA/CS nanofibers matrix enhances the biomedical functionality of CA@PLGA/CS nanofibers, making them promising materials for infected wound healing and nursing care applications.

Graphical abstract