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<p>This research biosynthesized ZnO nanoparticles from zinc acetate (ZnC<sub>4</sub>H<sub>6</sub>O<sub>4</sub>) using solid <i>Saccharum officinarum</i> (jaggery) aqueous extracts, a reducing and stabilizing agent. UV–Vis analysis showed a peak at 356&#xa0;nm. FTIR spectra revealed functional groups with O–H stretching at 3391&#xa0;cm⁻<sup>1</sup>, N–H bending at 1662&#xa0;cm⁻<sup>1</sup>, C–C stretching at 1405&#xa0;cm⁻<sup>1</sup>, and O–H bending at 913&#xa0;cm⁻<sup>1</sup>. XRD analysis showed distinct peaks at 31.8°, 34.5°, 36.3°, 47.6°, 56.7°, 63.0°, and 66.5°. FESEM images revealed a nanoflower structure with a size of 500&#xa0;nm and EDS indicated 43.37% Zn by weight. SO–ZnO NPs inhibited ABTS radicals by 41% at 100&#xa0;μg/mL and demonstrated 81.8% tyrosinase and 78.6% elastase inhibition. Cytotoxicity was observed above 20&#xa0;μg/mL in RAW 264.7 cells, with 42.9% inhibition of NO production at 10&#xa0;μg/mL. Anti-inflammatory effects were shown through reduced iNOS and COX-2 expression. These findings suggest the potential to access further biomedical applications for SO–ZnO NPs.</p> Graphical Abstract <p></p>

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Biogenic synthesis of bioactive zinc nanoparticles from Saccharum officinarum (Jaggery) for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Muhammad Awais Farooqi,
  • Sehui Kim,
  • Sungmin Bae,
  • Sungeun Bae,
  • Farzana Kausar,
  • Hafiz Muhammad Umer Farooqi,
  • Dong-Sun Lee,
  • Taeyoung Kang,
  • Chul Ung Kang

摘要

This research biosynthesized ZnO nanoparticles from zinc acetate (ZnC4H6O4) using solid Saccharum officinarum (jaggery) aqueous extracts, a reducing and stabilizing agent. UV–Vis analysis showed a peak at 356 nm. FTIR spectra revealed functional groups with O–H stretching at 3391 cm⁻1, N–H bending at 1662 cm⁻1, C–C stretching at 1405 cm⁻1, and O–H bending at 913 cm⁻1. XRD analysis showed distinct peaks at 31.8°, 34.5°, 36.3°, 47.6°, 56.7°, 63.0°, and 66.5°. FESEM images revealed a nanoflower structure with a size of 500 nm and EDS indicated 43.37% Zn by weight. SO–ZnO NPs inhibited ABTS radicals by 41% at 100 μg/mL and demonstrated 81.8% tyrosinase and 78.6% elastase inhibition. Cytotoxicity was observed above 20 μg/mL in RAW 264.7 cells, with 42.9% inhibition of NO production at 10 μg/mL. Anti-inflammatory effects were shown through reduced iNOS and COX-2 expression. These findings suggest the potential to access further biomedical applications for SO–ZnO NPs.

Graphical Abstract