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<p>Cardiovascular diseases (CVDs) are caused by a combination of genetic, environmental, and behavioral factors, making them complex and difficult to treat, predict, and prevent. In this study, a three-dimensional scaffold was designed to mimic the environment of an artificial heart. Data science, bioinformatics, and experimental design were used to create precision biomaterials for cardiac development. Using electrospinning and 3D printing techniques, three different structures representing the pericardium, myocardium, fleshy trabeculae, and endocardium were developed. These scaffolds were fabricated from a mixture of type I collagen and polycaprolactone (PCL), and their biocompatibility was evaluated using human fibroblasts. This research is innovative because the device was developed using type I collagen extracted from chicken skin, which closely resembles human collagen and helps reduce costs. In vitro evaluations of the various components demonstrate that the scaffold is suitable for cell growth and could be applied in tissue engineering.</p> Graphical abstract <p></p>

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Heart-like structure coated with biomimetic scaffolds obtained by 3D electrospinning

  • 期刊论文

  • 发表日期：

    2025年4月28日

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  • Josué Jiménez Vázquez,
  • Rocío Guadalupe Casañas Pimentel,
  • Eduardo San Martín Martínez

摘要

Cardiovascular diseases (CVDs) are caused by a combination of genetic, environmental, and behavioral factors, making them complex and difficult to treat, predict, and prevent. In this study, a three-dimensional scaffold was designed to mimic the environment of an artificial heart. Data science, bioinformatics, and experimental design were used to create precision biomaterials for cardiac development. Using electrospinning and 3D printing techniques, three different structures representing the pericardium, myocardium, fleshy trabeculae, and endocardium were developed. These scaffolds were fabricated from a mixture of type I collagen and polycaprolactone (PCL), and their biocompatibility was evaluated using human fibroblasts. This research is innovative because the device was developed using type I collagen extracted from chicken skin, which closely resembles human collagen and helps reduce costs. In vitro evaluations of the various components demonstrate that the scaffold is suitable for cell growth and could be applied in tissue engineering.

Graphical abstract