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<p>Due to their compositional similarities to bone, hydroxyapatite (HA)-based materials are used as bioactive ceramics for musculoskeletal repair. However, because of&#xa0;the lack of any inherent antibacterial properties, HA scaffolds have higher possibilities of post-surgical bacterial infections. The goal of this research is to fabricate alternate antibacterial and cytocompatible bone tissue engineering scaffolds using cobalt oxide (CoO)- and manganese dioxide (MnO<sub>2</sub>)-doped HA and plant-sourced curcumin from turmeric. Characterization results show no negative effects in phase and microstructure&#xa0;because of doping. When dopants and curcumin are combined, the antibacterial efficacy against <i>S. aureus</i> is ~ 95% after 24&#xa0;h. The addition of dopants does not result in any cytotoxicity with the NIH3T3 cell line, and the bioactivity of this delivery system is confirmed in a physiological pH of 7.4. In summary, our findings provide an alternate method for manufacturing antibacterial scaffolds for orthopedic and dental applications employing curcumin-loaded CoO–MnO<sub>2</sub>-doped HA.</p> Graphical abstract <p></p>

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Manganese dioxide- and cobalt oxide-doped hydroxyapatite with curcumin for orthopedic and dental applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月14日

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  • Joel Pilli,
  • Gwenevere Gatto,
  • Sameer Jain,
  • Arjak Bhattacharjee

摘要

Due to their compositional similarities to bone, hydroxyapatite (HA)-based materials are used as bioactive ceramics for musculoskeletal repair. However, because of the lack of any inherent antibacterial properties, HA scaffolds have higher possibilities of post-surgical bacterial infections. The goal of this research is to fabricate alternate antibacterial and cytocompatible bone tissue engineering scaffolds using cobalt oxide (CoO)- and manganese dioxide (MnO2)-doped HA and plant-sourced curcumin from turmeric. Characterization results show no negative effects in phase and microstructure because of doping. When dopants and curcumin are combined, the antibacterial efficacy against S. aureus is ~ 95% after 24 h. The addition of dopants does not result in any cytotoxicity with the NIH3T3 cell line, and the bioactivity of this delivery system is confirmed in a physiological pH of 7.4. In summary, our findings provide an alternate method for manufacturing antibacterial scaffolds for orthopedic and dental applications employing curcumin-loaded CoO–MnO2-doped HA.

Graphical abstract