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<p>Rifampicin is an antibiotic used to treat various types of bacterial infections, including leprosy, tuberculosis (TB), and other microbial disease. It is always used together with other antibiotics for effective treatments. However, it has short-term bioavailability and less aqueous solubility in the physiological milieu in clinical development, suggesting finding a new strategy. We prepared rifampicin-loaded pH-responsive RIF@ZIF-L nanoparticles for wound healing application. We investigated the physicochemical characteristics of RIF@ZIF-L nanoparticles in terms of crystalline nature, morphology, and particle size using XRD, SEM, TEM, and BET study. The biocompatibility and cytotoxicity of RIF@ZIF-L were examined against fibroblast L929 cell lines and red blood cells (RBC).&#xa0;In vitro&#xa0;studies exhibit that RIF@ZIF-L nanoparticles potentially enhanced the biosafety against L929 cells and RBC. The results of the pH-responsive drug release assay show admirable rifampicin release in an acidic milieu and without release in a physiological milieu. Wound scratch assay outcomes showed that the RIF@ZIF-L nanoparticle-treated group showed a quick cell migration and regeneration process. In the antibacterial activity, nanoparticles exhibit dose-dependent growth inhibition against pathogens. The overall investigations indicate that RIF@ZIF-L nanoparticles are suitable and efficient materials for pH-responsive wounds after thoracic operation.</p> Graphical abstract <p></p>

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A feasible strategy for fabricating a pH-responsive rifampicin-loaded zeolite imidazole nanoframeworks for the potent treatment of wounds after thoracic operation

  • 期刊论文

  • 发表日期：

    2025年4月9日

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  • Bowei Qiao,
  • Jie Lv,
  • Qiong Wu

摘要

Rifampicin is an antibiotic used to treat various types of bacterial infections, including leprosy, tuberculosis (TB), and other microbial disease. It is always used together with other antibiotics for effective treatments. However, it has short-term bioavailability and less aqueous solubility in the physiological milieu in clinical development, suggesting finding a new strategy. We prepared rifampicin-loaded pH-responsive RIF@ZIF-L nanoparticles for wound healing application. We investigated the physicochemical characteristics of RIF@ZIF-L nanoparticles in terms of crystalline nature, morphology, and particle size using XRD, SEM, TEM, and BET study. The biocompatibility and cytotoxicity of RIF@ZIF-L were examined against fibroblast L929 cell lines and red blood cells (RBC). In vitro studies exhibit that RIF@ZIF-L nanoparticles potentially enhanced the biosafety against L929 cells and RBC. The results of the pH-responsive drug release assay show admirable rifampicin release in an acidic milieu and without release in a physiological milieu. Wound scratch assay outcomes showed that the RIF@ZIF-L nanoparticle-treated group showed a quick cell migration and regeneration process. In the antibacterial activity, nanoparticles exhibit dose-dependent growth inhibition against pathogens. The overall investigations indicate that RIF@ZIF-L nanoparticles are suitable and efficient materials for pH-responsive wounds after thoracic operation.

Graphical abstract