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<p>The study utilized poly(D,L-lactide-co-glycolide)-block-polyethylene glycol (PEG) (PLGA-PEG) to encapsulate cabazitaxel (CTX) and (imidazoleH)[trans-RuCl<sub>4</sub>(DMSO-S)(Im)] (NAMI-A) into nanoparticles (CN-NPs). The nanoparticles displayed several advantageous characteristics, such as a spherical morphology, small size (84.25 ± 1.36&#xa0;nm), remarkably excellent encapsulation efficiency, and drug loading. The NPs had a smooth surface morphology, appropriate negative charge (−&#xa0;21.2 ± 2.1&#xa0;mV), optimal stability, and gradual release. The CN-NPs are implicated in the proliferation of KYSE-270 cells. Significantly, both NAMI-A and CTX, in both their free and nanoparticulate states, exhibited lower toxicity toward HUVECs when compared to KYSE-270 cells. The morphological changes of both cells were examined by biochemical staining, and the apoptotic mode of cell death was confirmed. BAX, Caspase-3, -8, and -9 expression levels were examined in KYSE-270 cells subjected to the different NPs. The findings indicate that the simultaneous delivery of CTX and NAMI-A nanoparticles can potentially remove esophageal cancer efficiently.</p> Graphical abstract <p></p>

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In vitro anticancer activity of encapsulated polymeric nanoparticles of cabazitaxel and ruthenium compound NAMI-A drugs in the treatment of esophogeal cancer

  • 期刊论文

  • 发表日期：

    2025年3月10日

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  • Jiani Zhang,
  • Xiaoli Mei,
  • E Zheng,
  • Weipeng Hu,
  • Mei Yang

摘要

The study utilized poly(D,L-lactide-co-glycolide)-block-polyethylene glycol (PEG) (PLGA-PEG) to encapsulate cabazitaxel (CTX) and (imidazoleH)[trans-RuCl4(DMSO-S)(Im)] (NAMI-A) into nanoparticles (CN-NPs). The nanoparticles displayed several advantageous characteristics, such as a spherical morphology, small size (84.25 ± 1.36 nm), remarkably excellent encapsulation efficiency, and drug loading. The NPs had a smooth surface morphology, appropriate negative charge (− 21.2 ± 2.1 mV), optimal stability, and gradual release. The CN-NPs are implicated in the proliferation of KYSE-270 cells. Significantly, both NAMI-A and CTX, in both their free and nanoparticulate states, exhibited lower toxicity toward HUVECs when compared to KYSE-270 cells. The morphological changes of both cells were examined by biochemical staining, and the apoptotic mode of cell death was confirmed. BAX, Caspase-3, -8, and -9 expression levels were examined in KYSE-270 cells subjected to the different NPs. The findings indicate that the simultaneous delivery of CTX and NAMI-A nanoparticles can potentially remove esophageal cancer efficiently.

Graphical abstract