Scholarlink

<p>Today, bacterial infections have jumped to an extremely critical health crisis and have become one of the most pressing health threats. 10 million people will die per year because of bacterial infections by 2050. There is an urgent need to develop a new antibacterial strategy to deal with bacterial infections. In this study, PEG-modified superparamagnetic iron oxide nanoparticles (PEG-SPIONs) were prepared using an ultra-straightforward high thermal decomposition method. The synthesized PEG-SPIONs showed excellent biocompatibility, stability, superparamagnetic, and photocatalytic properties. It is worth noting that PEG-SPIONs have excellent photocatalytic antimicrobial activity against <i>E. coli</i> and <i>S. aureus</i>. In addition, the antimicrobial mechanism revealed that PEG-SPIONs could inhibit the formation of bacterial biofilms and cause disruption of bacterial biofilms, the crumple or rupture of bacteria, triggering inclusion leakage and Reactive Oxygen Species production, while avoiding inducing drug resistance. In conclusion, PEG-SPIONs have great potential for application as an efficient photocatalytic antibacterial material.</p> Graphical abstract <p>The synthesis (a) and antibacterial schematic diagram (b) of PEG-SPIONs. We prepared PEG-modified superparamagnetic iron oxide nanoparticles (PEG-SPIONs) using an ultra-simple pyrolysis method. The synthesized PEG-SPIONs showed good biocompatibility, stability, superparamagnetic, and photocatalytic properties. It is worth noting that PEG-SPIONs have excellent photocatalytic antimicrobial activity against E. coli and S. aureus. In addition, the antimicrobial mechanism revealed that PEG-SPIONs could inhibit the formation of bacterial biofilms and cause disruption of bacterial biofilms, the crumple or rupture of bacteria, leading to leakage of inclusions and the generation of reactive oxygen species (ROS) without inducing the drug resistance of bacteria. In conclusion, the prepared PEG-SPIONs are promising for photocatalytic synergistic antimicrobial applications. This work serves as a reference for developing various functional photocatalytic nanomaterials for exploitation strategies and applications.</p> <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Photocatalytic antibacterial properties and mechanism of PEG-modified superparamagnetic iron oxide nanoparticles

  • 期刊论文

  • 发表日期：

    2025年3月14日

查看全文
  • Jiantao Wang,
  • Xuechao Shi,
  • Shuxian Hou,
  • Yimei Wang,
  • Zihao Xu,
  • Ming He,
  • Yu Liu,
  • Fei Ge,
  • Rongrong Li,
  • Jun Wang

摘要

Today, bacterial infections have jumped to an extremely critical health crisis and have become one of the most pressing health threats. 10 million people will die per year because of bacterial infections by 2050. There is an urgent need to develop a new antibacterial strategy to deal with bacterial infections. In this study, PEG-modified superparamagnetic iron oxide nanoparticles (PEG-SPIONs) were prepared using an ultra-straightforward high thermal decomposition method. The synthesized PEG-SPIONs showed excellent biocompatibility, stability, superparamagnetic, and photocatalytic properties. It is worth noting that PEG-SPIONs have excellent photocatalytic antimicrobial activity against E. coli and S. aureus. In addition, the antimicrobial mechanism revealed that PEG-SPIONs could inhibit the formation of bacterial biofilms and cause disruption of bacterial biofilms, the crumple or rupture of bacteria, triggering inclusion leakage and Reactive Oxygen Species production, while avoiding inducing drug resistance. In conclusion, PEG-SPIONs have great potential for application as an efficient photocatalytic antibacterial material.

Graphical abstract

The synthesis (a) and antibacterial schematic diagram (b) of PEG-SPIONs. We prepared PEG-modified superparamagnetic iron oxide nanoparticles (PEG-SPIONs) using an ultra-simple pyrolysis method. The synthesized PEG-SPIONs showed good biocompatibility, stability, superparamagnetic, and photocatalytic properties. It is worth noting that PEG-SPIONs have excellent photocatalytic antimicrobial activity against E. coli and S. aureus. In addition, the antimicrobial mechanism revealed that PEG-SPIONs could inhibit the formation of bacterial biofilms and cause disruption of bacterial biofilms, the crumple or rupture of bacteria, leading to leakage of inclusions and the generation of reactive oxygen species (ROS) without inducing the drug resistance of bacteria. In conclusion, the prepared PEG-SPIONs are promising for photocatalytic synergistic antimicrobial applications. This work serves as a reference for developing various functional photocatalytic nanomaterials for exploitation strategies and applications.