<p>Nanogenerators are emerging as a transformative technology in implantable medical devices, offering new solutions to the challenge of powering these systems. This article delves into the different types of nanogenerators, each with unique mechanisms and designs tailored for compatibility with the human body. The selection of materials, from biodegradable to flexible options, is critical in ensuring biocompatibility and long-term functionality. Nanogenerators have demonstrated effectiveness across various human body systems and in treating different types of diseases, significantly enhancing treatment outcomes. Additionally, the article discusses the technical challenges related to material stability and power efficiency, while also considering the future potential of these devices in advancing medical research.</p> Graphical abstract <p></p>