<p>Triply periodic minimal surfaces (TPMSs) have been extensively studied in many fields of engineering, including bone tissue scaffolds. Recent advancements in manufacturing have enabled the three-dimensional printing of ceramic porous architectures; however, their intrinsic brittleness limits its practical applications. It has been observed that the ossicles of the knobby starfish exhibit a mineralized TPMS structure with lattice distortions (i.e., dislocations), which effectively deviate the crack propagation and enhance the fracture energy. In this article, the aforementioned toughening mechanism has been introduced in a TPMS architecture. We employed finite element models to analyze the effective mechanical properties of the structures under compression, both in the elastic and post-elastic regimes. Our analysis reveals that the introduction of the dislocation induces variations in both elastic and fracture properties of the structures. With particular reference to the fracture behavior, a suitable oriented edge dislocation is able to alter the crack nucleation and propagation, resulting in a tougher structure. Both the elastic and fracture phenomena can be enhanced or reduced by changing the dislocation density.</p>