Scholarlink

Background <p>Scalp and neck (SN) melanoma demonstrates the worst prognosis among all cutaneous head and neck melanomas (CHNMs). The objective of this study was to evaluate the melanoma-specific survival (MSS) in SN melanoma compared with other CHNM after the widespread clinical adaptation of sentinel lymph node biopsy in 2011 and asses whether tumor site is associated with distant metastases.</p> Patients and Methods <p>A retrospective cohort study was carried out using Surveillance, Epidemiology, and End Result (SEER) data from 2011 to 2020, comprising 13,825 CHNM cases. Cox and multinomial logistic regression models were used to estimate adjusted hazard ratios and adjusted odds ratio (aORs).</p> Results <p>SN melanoma was associated with significantly worse MSS, with 5-year MSS rates of 76.5% versus 82.7%. Multivariable analysis showed SN melanoma had worse MSS (aHR 1.28; 95% confidence interval [CI] 1.16–1.41) and higher odds of presenting with lung metastases (aOR 2.39; 95% CI 1.35–4.25) and multisite metastases (aOR 2.23; 95% CI 1.28–3.88). A limitation of the study was that the SEER database groups SN together despite previous research suggesting that the scalp component contributes to most of the poor prognoses.</p> Conclusions <p>SN melanoma is associated with worse MSS among all CHNMs despite the routine use of SLNB. SN melanoma also follows a distinct metastatic pattern to solid organs, particularly to the lungs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prognostic Implications of Primary Site in Cutaneous Head and Neck Melanoma After the Implementation of Sentinel Node Biopsy: A SEER-Based Analysis (2011–2020)

  • 期刊论文

  • 发表日期：

    2026年3月9日

查看全文
  • Simatul Rashid,
  • Catherine Yu,
  • Nicholas Gulati,
  • Parul Agarwal,
  • Maaike van Gerwen

摘要

Background

Scalp and neck (SN) melanoma demonstrates the worst prognosis among all cutaneous head and neck melanomas (CHNMs). The objective of this study was to evaluate the melanoma-specific survival (MSS) in SN melanoma compared with other CHNM after the widespread clinical adaptation of sentinel lymph node biopsy in 2011 and asses whether tumor site is associated with distant metastases.

Patients and Methods

A retrospective cohort study was carried out using Surveillance, Epidemiology, and End Result (SEER) data from 2011 to 2020, comprising 13,825 CHNM cases. Cox and multinomial logistic regression models were used to estimate adjusted hazard ratios and adjusted odds ratio (aORs).

Results

SN melanoma was associated with significantly worse MSS, with 5-year MSS rates of 76.5% versus 82.7%. Multivariable analysis showed SN melanoma had worse MSS (aHR 1.28; 95% confidence interval [CI] 1.16–1.41) and higher odds of presenting with lung metastases (aOR 2.39; 95% CI 1.35–4.25) and multisite metastases (aOR 2.23; 95% CI 1.28–3.88). A limitation of the study was that the SEER database groups SN together despite previous research suggesting that the scalp component contributes to most of the poor prognoses.

Conclusions

SN melanoma is associated with worse MSS among all CHNMs despite the routine use of SLNB. SN melanoma also follows a distinct metastatic pattern to solid organs, particularly to the lungs.