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Background <p>Surgery is a mainstay of treatment for gastrointestinal cancers, yet it often leads to postoperative complications and poorer health outcomes. (P)rehabilitation may improve postoperative outcomes; however, optimal delivery modes remain unclear. Traditional face-to-face models may be inaccessible for patients in geographically dispersed countries. This pilot trial was designed to determine the feasibility and acceptability of a virtual multimodal (p)rehabilitation programme in patients undergoing gastrointestinal cancer surgery.</p> Methods <p>The PRIORITY-CONNECT 2 Pilot trial was a multicentre, assessor-blinded, randomised controlled feasibility pilot trial. Consenting adults scheduled for gastrointestinal cancer surgery were randomised 1:1 to receive a virtual multimodal (p)rehabilitation programme (up to 6 weeks preoperatively and 3 months postoperatively) plus usual care or usual care alone. The virtual hub provided specialised multidisciplinary care by a team that included a physiotherapist, psychologist, dietitian, specialist nurse, social worker, and geriatrician. Primary outcomes included intervention feasibility (in terms of uptake, retention, and adherence) and acceptability. Secondary outcomes included postoperative complications within 30 days following surgery, health-related quality of life, and days at home within 30 and 90 days of surgery.</p> Results <p>We randomised 20 participants (intervention n = 11, control n = 9). Uptake among eligible participants was 65%, retention 95%, and adherence 74%. Overall satisfaction with the programme was high; 78% of respondents reported that they were either “satisfied” or “extremely satisfied.”</p> Conclusions <p>The results of this pilot trial demonstrate both feasibility and acceptability of the intervention. The full-scale PRIORITY-CONNECT 2 Trial will determine the effectiveness of a virtual multimodal (p)rehabilitation programme for patients undergoing colorectal cancer surgery.</p> <p><i>Trial registration</i></p> <p>This trial was registered prospectively with the National Library of Medicine ClinicalTrials.gov Registry (NCT06212700) on 8th January 2024.</p>

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Acceptability and Feasibility of a Virtual Multimodal (P)Rehabilitation Programme for Gastrointestinal Cancer Patients: The PRIORITY-CONNECT 2 Pilot Randomised Controlled Trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月14日

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  • Jack Reeves,
  • Cherry Koh,
  • Allan Ben Smith,
  • Helen Mohan,
  • Sharon Carey,
  • Stephen Smith,
  • Thomas Poulton,
  • Vicki Patton,
  • Kate White,
  • Liliana Laranjo,
  • Mbathio Dieng,
  • Xiaoqiu Liu,
  • Linda Denehy,
  • Kate Wilson,
  • Margaret Allman-Farinelli,
  • Phyllis Butow,
  • Bernhard Riedel,
  • Rachael L. Morton,
  • Leanne Hassett,
  • Qiang Li,
  • Kim Delbaere,
  • Olivia Martin,
  • Haryana M. Dhillon,
  • Briana Shailer,
  • Gaynor Beardsworth,
  • Marine Salter,
  • Kathryn Cherry,
  • Freya Rubie,
  • Lauren Reece,
  • Aveline Chan,
  • Rihan Shahab,
  • Olivia Dwyer,
  • Kaylene Pring,
  • Derek Cunningham,
  • Kym Sheehan,
  • Gino Iori,
  • Rika Johnander,
  • Claire Jeon,
  • Nicholas Hirst,
  • Sascha Karunaratne,
  • Annie Zhou,
  • Owen Hutchings,
  • Michael Solomon,
  • Daniel Steffens,
  • Amy Cao,
  • Nima Ahmadi,
  • Vinna An,
  • Nabila Ansari,
  • Fernando Arduini,
  • Manpreet Aulakh,
  • Kirk Austin,
  • Corina Behrenbruch,
  • Nathasha Brice,
  • Kimberley Bostock,
  • Christopher Byrne,
  • Ju Young Cheong,
  • Joseph Cherng Huei Kong,
  • David Clark,
  • Jessica Connell,
  • Dayan De Fontgalland,
  • Basil D’Souza,
  • Deshitha Gardiye Hewawasam Thuduwage,
  • Chris Gillespie,
  • Stephen Jancewicz,
  • Rajni Lal,
  • Jerome Laurence,
  • Peter Lee,
  • Angus Lee,
  • Jacob McCormick,
  • Elizabeth Murphy,
  • Toan Pham,
  • Carlo Pulitano,
  • Tarik Sammour,
  • Charbel Sandroussi,
  • Michael Suen,
  • Andrew Sutherland,
  • Douglas Stupart,
  • Howard Tang,
  • Cheryl Tobler,
  • Lilian Whitehead,
  • Robert Winn,
  • Danette Bianca Wright,
  • Justing Yeun

摘要

Background

Surgery is a mainstay of treatment for gastrointestinal cancers, yet it often leads to postoperative complications and poorer health outcomes. (P)rehabilitation may improve postoperative outcomes; however, optimal delivery modes remain unclear. Traditional face-to-face models may be inaccessible for patients in geographically dispersed countries. This pilot trial was designed to determine the feasibility and acceptability of a virtual multimodal (p)rehabilitation programme in patients undergoing gastrointestinal cancer surgery.

Methods

The PRIORITY-CONNECT 2 Pilot trial was a multicentre, assessor-blinded, randomised controlled feasibility pilot trial. Consenting adults scheduled for gastrointestinal cancer surgery were randomised 1:1 to receive a virtual multimodal (p)rehabilitation programme (up to 6 weeks preoperatively and 3 months postoperatively) plus usual care or usual care alone. The virtual hub provided specialised multidisciplinary care by a team that included a physiotherapist, psychologist, dietitian, specialist nurse, social worker, and geriatrician. Primary outcomes included intervention feasibility (in terms of uptake, retention, and adherence) and acceptability. Secondary outcomes included postoperative complications within 30 days following surgery, health-related quality of life, and days at home within 30 and 90 days of surgery.

Results

We randomised 20 participants (intervention n = 11, control n = 9). Uptake among eligible participants was 65%, retention 95%, and adherence 74%. Overall satisfaction with the programme was high; 78% of respondents reported that they were either “satisfied” or “extremely satisfied.”

Conclusions

The results of this pilot trial demonstrate both feasibility and acceptability of the intervention. The full-scale PRIORITY-CONNECT 2 Trial will determine the effectiveness of a virtual multimodal (p)rehabilitation programme for patients undergoing colorectal cancer surgery.

Trial registration

This trial was registered prospectively with the National Library of Medicine ClinicalTrials.gov Registry (NCT06212700) on 8th January 2024.