Background In locally advanced pancreatic adenocarcinomas (LA-PDAC) when both common hepatic artery and portal vein encasement coexist, classical right-to-left dissection with vascular resection is difficult to achieve.<CitationRef CitationID="CR1">1</CitationRef> We describe an alternative approach named left-to-right pancreatoduodenectomy at splenic vessels in which the central part of the dissection is carried out last and the reversed splenic artery is used to reconstruct the hepatic artery.<CitationRef CitationID="CR2">2</CitationRef> Patient and Methods The patient was a 76-year-old woman with both transverse colonic cancer and LA-PDAC (common hepatic artery and portal vein encasement with venous cavernoma) who underwent 6 months of GEMOX induction treatment with carbohydrate antigen 19.9 (CA 19-9) normalization. Dissection steps included: (1) early mesenteric-portal shunting to bypass portal cavernoma;<CitationRef CitationID="CR3">3</CitationRef> (2) mesenteric approach to the superior mesenteric antigen (SMA) with jejunal section and SMA isolation;<CitationRef CitationID="CR4">4</CitationRef> (3) retropancreatic tunnel on the left of the SMA with pancreatic body section;<CitationRef CitationID="CR1">1</CitationRef> (4) splenic vessel dissection with distal splenic artery section and a distal venous-spleno renal shunt fashioning;<CitationRef AdditionalCitationIDS="CR6" CitationID="CR5">5</CitationRef>–<CitationRef CitationID="CR7">7</CitationRef> (5) proper and common hepatic artery section and reconstruction by splenic artery reversal;<CitationRef CitationID="CR2">2</CitationRef> and (6) digestive reconstruction with pancreatogastrostomy. Right colectomy was performed en bloc because of synchronous colonic cancer. Results Surgery lasted 360 min. Pathology showed pT4N1R0 pancreatic adenocarcinomas and a T3N0 colonic adenocarcinomas. Conclusions In LA-PDAC with both common hepatic artery and portal vein encasement, left-to-right could serve as an alternative approach in high-volume centers for expert pancreatic/vascular surgeons. The early section of the mesenteric vein with temporary venous shunting and the distal splenorenal shunt can reduce bleeding. Section and rotation of the splenic artery facilitate common hepatic artery resection and reconstruction.

Left-to-Right Pancreatoduodenectomy at Splenic Vessels for Locally Advanced Pancreatic Tumors with Portal Vein and Common Hepatic Artery Encasement

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发表日期：

2026年1月20日

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Pietro Addeo,
Chloé Paul,
Ivan Marchitelli,
Pierre De Mathelin,
Philippe Bachellier

摘要

Background

In locally advanced pancreatic adenocarcinomas (LA-PDAC) when both common hepatic artery and portal vein encasement coexist, classical right-to-left dissection with vascular resection is difficult to achieve.¹ We describe an alternative approach named left-to-right pancreatoduodenectomy at splenic vessels in which the central part of the dissection is carried out last and the reversed splenic artery is used to reconstruct the hepatic artery.²

Patient and Methods

The patient was a 76-year-old woman with both transverse colonic cancer and LA-PDAC (common hepatic artery and portal vein encasement with venous cavernoma) who underwent 6 months of GEMOX induction treatment with carbohydrate antigen 19.9 (CA 19-9) normalization. Dissection steps included: (1) early mesenteric-portal shunting to bypass portal cavernoma;³ (2) mesenteric approach to the superior mesenteric antigen (SMA) with jejunal section and SMA isolation;⁴ (3) retropancreatic tunnel on the left of the SMA with pancreatic body section;¹ (4) splenic vessel dissection with distal splenic artery section and a distal venous-spleno renal shunt fashioning;^5–7 (5) proper and common hepatic artery section and reconstruction by splenic artery reversal;² and (6) digestive reconstruction with pancreatogastrostomy. Right colectomy was performed en bloc because of synchronous colonic cancer.

Results

Surgery lasted 360 min. Pathology showed pT4N1R0 pancreatic adenocarcinomas and a T3N0 colonic adenocarcinomas.

Conclusions

In LA-PDAC with both common hepatic artery and portal vein encasement, left-to-right could serve as an alternative approach in high-volume centers for expert pancreatic/vascular surgeons. The early section of the mesenteric vein with temporary venous shunting and the distal splenorenal shunt can reduce bleeding. Section and rotation of the splenic artery facilitate common hepatic artery resection and reconstruction.