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Background <p>Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin (99mTc-GSA) scintigraphy is used as a preoperative liver reserve test. This study investigated whether tumor radioactivity in 99mTc-GSA scintigraphy correlates with the survival of patients with hepatocellular carcinoma (HCC).</p> Patients and Methods <p>In total, 115 patients who underwent 99mTc-GSA scintigraphy before hepatectomy for HCC were included in this study. Tumor radioactivity in 99mTc-GSA scintigraphy was assessed, and its prognostic relevance to disease-free survival (DFS) and overall survival (OS) in patients with HCC was evaluated.</p> Results <p>The hepatic uptake index in 99mTc-GSA scintigraphy was associated with liver fibrosis. HCC with high tumor radioactivity in 99mTc-GSA scintigraphy showed high expression of the asialoglycoprotein receptor. Tumor radioactivity in 99mTc-GSA scintigraphy was associated with histologic differentiation grade and tumor size. Low tumor radioactivity was identified as an independent poor prognostic predictor of both DFS and OS.</p> Conclusions <p>99mTc-GSA scintigraphy may be valuable not only for evaluating hepatic function before hepatectomy for HCC but also for assessing the aggressive biology of a tumor.</p>

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Tumor Radioactivity in 99mTc-GSA Scintigraphy Predicts Oncological Outcomes in Patients Who Underwent Hepatectomy for Hepatocellular Carcinoma

  • 期刊论文

  • 发表日期：

    2025年6月17日

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  • Kenei Furukawa,
  • Koichiro Haruki,
  • Ken Watanabe,
  • Kazutaka Gomisawa,
  • Masayuki Shimoda,
  • Shinji Onda,
  • Yoshihiro Shirai,
  • Michinori Matsumoto,
  • Masashi Tsunematsu,
  • Toru Ikegami

摘要

Background

Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin (99mTc-GSA) scintigraphy is used as a preoperative liver reserve test. This study investigated whether tumor radioactivity in 99mTc-GSA scintigraphy correlates with the survival of patients with hepatocellular carcinoma (HCC).

Patients and Methods

In total, 115 patients who underwent 99mTc-GSA scintigraphy before hepatectomy for HCC were included in this study. Tumor radioactivity in 99mTc-GSA scintigraphy was assessed, and its prognostic relevance to disease-free survival (DFS) and overall survival (OS) in patients with HCC was evaluated.

Results

The hepatic uptake index in 99mTc-GSA scintigraphy was associated with liver fibrosis. HCC with high tumor radioactivity in 99mTc-GSA scintigraphy showed high expression of the asialoglycoprotein receptor. Tumor radioactivity in 99mTc-GSA scintigraphy was associated with histologic differentiation grade and tumor size. Low tumor radioactivity was identified as an independent poor prognostic predictor of both DFS and OS.

Conclusions

99mTc-GSA scintigraphy may be valuable not only for evaluating hepatic function before hepatectomy for HCC but also for assessing the aggressive biology of a tumor.