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Background <p>Findings have shown that preoperative serum interleukin 6 (IL-6) concentrations are associated with treatment response and prognosis of patients with esophageal cancer. However, it has been unclear whether IL-6 concentrations after minimally invasive esophagectomy (MIE) have an impact on nutritional status and prognosis.</p> Methods <p>The cohort of this retrospective study comprised 336 patients who had undergone MIE with R0 for esophageal cancer from August 2020 to August 2022. The study investigated the relationship between postoperative serum IL-6 concentrations and outcomes.</p> Results <p>The study created low-IL-6 (&lt;60&#xa0;pg/mL) and high-IL-6 (≥60&#xa0;pg/mL) groups according to the upper-quartile postoperative serum IL-6 concentration 1&#xa0;day after MIE. The high-IL-6 group had a significantly worse overall survival (OS) (2-year OS rate, 69.8% in high-IL-6 vs 80.6% in low-IL-6 group; <i>p</i> = 0.004). A high IL-6 was independently and significantly associated with poor OS (odds ratio, 1.548; 95% confidence interval, 1.027–2.335; <i>p</i> = 0.037). Several indices of malnutrition, including the modified Glasgow prognostic score (mGPS), 1 month after surgery, were significantly lower in the high-IL-6 group than in the low-IL-6 group. Multivariate analysis identified high serum IL-6 concentration 1&#xa0;day after surgery as an independent risk factor for malnutrition.</p> Conclusion <p>The ultra-early postoperative serum IL-6 concentration has a negative impact on the nutrition and prognosis of patients who have undergone MIE for esophageal cancer. Decreasing serum IL-6 concentrations after esophagectomy may improve nutritional status and prognosis. It may be important for perioperative management and treatment strategies to target IL-6 after esophageal cancer surgery.</p>

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Postoperative Serum Interleukin 6 Concentrations Are Associated With Nutritional Status and Prognosis of Esophageal Cancer in the Minimally Invasive Esophagectomy Era

  • 期刊论文

  • 发表日期：

    2025年5月24日

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  • Yuto Kubo,
  • Takeo Fujita,
  • Kazuma Sato,
  • Daisuke Kajiyama,
  • Kentaro Kubo,
  • Hiroyuki Daiko

摘要

Background

Findings have shown that preoperative serum interleukin 6 (IL-6) concentrations are associated with treatment response and prognosis of patients with esophageal cancer. However, it has been unclear whether IL-6 concentrations after minimally invasive esophagectomy (MIE) have an impact on nutritional status and prognosis.

Methods

The cohort of this retrospective study comprised 336 patients who had undergone MIE with R0 for esophageal cancer from August 2020 to August 2022. The study investigated the relationship between postoperative serum IL-6 concentrations and outcomes.

Results

The study created low-IL-6 (<60 pg/mL) and high-IL-6 (≥60 pg/mL) groups according to the upper-quartile postoperative serum IL-6 concentration 1 day after MIE. The high-IL-6 group had a significantly worse overall survival (OS) (2-year OS rate, 69.8% in high-IL-6 vs 80.6% in low-IL-6 group; p = 0.004). A high IL-6 was independently and significantly associated with poor OS (odds ratio, 1.548; 95% confidence interval, 1.027–2.335; p = 0.037). Several indices of malnutrition, including the modified Glasgow prognostic score (mGPS), 1 month after surgery, were significantly lower in the high-IL-6 group than in the low-IL-6 group. Multivariate analysis identified high serum IL-6 concentration 1 day after surgery as an independent risk factor for malnutrition.

Conclusion

The ultra-early postoperative serum IL-6 concentration has a negative impact on the nutrition and prognosis of patients who have undergone MIE for esophageal cancer. Decreasing serum IL-6 concentrations after esophagectomy may improve nutritional status and prognosis. It may be important for perioperative management and treatment strategies to target IL-6 after esophageal cancer surgery.