Background Hepatocellular carcinoma (HCC) associated with major vasculature tumor extension is considered an advanced stage of disease to which palliative radiotherapy or chemotherapy is proposed.<CitationRef CitationID="CR1">1</CitationRef>,<CitationRef CitationID="CR2">2</CitationRef> Surgical resection associated with chemotherapy or chemoembolization could be an opportunity to improve overall survival and recurrence-free survival in selected cases in a high-volume hepatobiliary center.<CitationRef CitationID="CR3">3</CitationRef>,<CitationRef CitationID="CR4">4</CitationRef> Moreover, it has been 25 years since Couinaud described the entity of a posterior liver located behind an axial plane crossing the portal bifurcation.<CitationRef CitationID="CR5">5</CitationRef> The aim of this video was to show how to reproduce such a resection technique. Methods We report the case of a 72-year-old male presenting with a 6 cm HCC developed in a well-compensated Child–Pugh A alcohol-related cirrhosis and localized in the dorsal liver sector. The tumor invaded the retrohepatic inferior vena cava (IVC) as well as segment 2 and the right posterior section glissonean pedicles. The initial management of the patient was performed outside of a reference center for hepatobiliary surgery and the tumor was initially considered unresectable. Transarterial chemoembolization was judged ineffective due to the size and location of the tumor. Initial treatment included 6 months of atezolizumab–bevacizumab, permitting tumor volume stability and enabling surgical resection. Results The procedure included an en bloc posterior hepatectomy (H1267)<CitationRef CitationID="CR6">6</CitationRef> with IVC resection and polytetrafluoroethylene (PTFE) graft replacement. A well-tolerated intermittent pedicle and IVC clamping of 30 min in total was used. The duration of surgery was 240 min, with 30 min of total vascular liver exclusion, and total blood loss was 650 mL. The patient was discharged on postoperative day 8. R0 resection was achieved and the patient was free of disease at 1 year post-surgery. Conclusion To our knowledge, this video reports the first posterior hepatectomy performed in clinical practice and demonstrates liver anatomy as described by Couinaud in 1999.<CitationRef CitationID="CR5">5</CitationRef> Moreover, complex vascular resections for HCC should be considered a valid therapeutic option in selected cases and high-volume hepatobiliary centers.

Posterior Hepatectomy and Inferior Vena Cava Graft Reconstruction for En Bloc Resection of a Hepatocellular Carcinoma: A Tribute to Couinaud’s Liver Anatomy Description

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2025年1月25日

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Bastien Le Floc’h,
Marie Livin,
Stylianos Tzedakis,
Fabien Robin,
Heithem Jeddou,
Karim Boudjema

摘要

Background

Hepatocellular carcinoma (HCC) associated with major vasculature tumor extension is considered an advanced stage of disease to which palliative radiotherapy or chemotherapy is proposed.^1,2 Surgical resection associated with chemotherapy or chemoembolization could be an opportunity to improve overall survival and recurrence-free survival in selected cases in a high-volume hepatobiliary center.^3,4 Moreover, it has been 25 years since Couinaud described the entity of a posterior liver located behind an axial plane crossing the portal bifurcation.⁵ The aim of this video was to show how to reproduce such a resection technique.

Methods

We report the case of a 72-year-old male presenting with a 6 cm HCC developed in a well-compensated Child–Pugh A alcohol-related cirrhosis and localized in the dorsal liver sector. The tumor invaded the retrohepatic inferior vena cava (IVC) as well as segment 2 and the right posterior section glissonean pedicles. The initial management of the patient was performed outside of a reference center for hepatobiliary surgery and the tumor was initially considered unresectable. Transarterial chemoembolization was judged ineffective due to the size and location of the tumor. Initial treatment included 6 months of atezolizumab–bevacizumab, permitting tumor volume stability and enabling surgical resection.

Results

The procedure included an en bloc posterior hepatectomy (H1267)⁶ with IVC resection and polytetrafluoroethylene (PTFE) graft replacement. A well-tolerated intermittent pedicle and IVC clamping of 30 min in total was used. The duration of surgery was 240 min, with 30 min of total vascular liver exclusion, and total blood loss was 650 mL. The patient was discharged on postoperative day 8. R0 resection was achieved and the patient was free of disease at 1 year post-surgery.

Conclusion

To our knowledge, this video reports the first posterior hepatectomy performed in clinical practice and demonstrates liver anatomy as described by Couinaud in 1999.⁵ Moreover, complex vascular resections for HCC should be considered a valid therapeutic option in selected cases and high-volume hepatobiliary centers.