PROMRIINE (PRe-operatory Magnetic Resonance Imaging is INEffective) Study: A Systematic Review and Meta-analysis of the Impact of Magnetic Resonance Imaging on Surgical Decisions and Clinical Outcomes in Women with Breast Cancer

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2024年7月27日

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André Mattar,
Marcelo Antonini,
Andressa Amorim,
Evandro Falaci Mateus,
Fabio Bagnoli,
Francisco Pimentel Cavalcante,
Guilherme Novita,
Lincon Jo Mori,
Marcelo Madeira,
Marina Diógenes,
Antônio Luiz Frasson,
Eduardo de Camargo Millen,
Fabrício Palermo Brenelli,
Lucas Miyake Okumura,
Felipe Zerwes

摘要

Background

The purpose of this study was to review and summarize the association between preoperative magnetic resonance imaging (MRI) and surgical outcomes in women with newly diagnosed invasive breast cancer from published randomized controlled trials (RCT).

Materials and Methods

Two independent researchers conducted a systematic review through a comprehensive search of electronic databases, including PubMed, Medline, Embase, Ovid, Cochrane Library, and Web of Science. If there was disagreement between the two reviewers, a third reviewer assessed the manuscript to determine whether it should be included for data extraction. The quality of the papers was assessed using the risk of bias tool, and the evidence was analyzed using GRADE. Meta-analyses using a fixed-effects model were used to estimate the pooled risk ratio (RR) and 95% confidence interval (CI).

Results

Initially, 21 studies were identified, 15 of which were observational comparative studies. A total of five RCTs were included, and they suggested that preoperative MRI significantly reduced the rate of immediate breast-conserving surgery and increased the risk for mastectomy.

Conclusions

From the RCT perspective, preoperative MRI for newly diagnosed invasive breast cancer did not improve surgical outcomes and may increase the risk of mastectomy.