<p>Paediatric neurological conditions pose many challenges for treatment because of the dynamic properties of the developing nervous system. Special therapeutic interventions are necessary to cope with these alterations because they are frequently impaired by the blood–brain barrier, which denies drugs access to the brain. Liposomes, a lipid carrier, present a promising option, making it possible to deliver a broad variety of drugs to desired locations within the central nervous system. One of the main benefits of liposomes is that they can cross the blood–brain barrier by mechanisms like endocytosis, facilitating controlled drug delivery, minimising toxicity, and enhancing bioavailability. This can be achieved by surface modification of liposomes, enhancing the bioavailability of drugs via oral, nasal, and intravenous routes. In paediatric neurological disorders, liposomes have a great potential in developing treatment approaches, which is discussed in this review. They provide potential therapeutic advantages for ailments like epilepsy, migraine, autism, ADHD, and brain tumours, highlighting their significance in aiding the management of these intricate conditions.</p> Graphical Abstract <p></p>