A Perspective on Evaluating Life Stage Differences in Drug Dosages for Drug Labeling and Instructions

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发表日期：

2024年8月20日

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Tianshu Gu,
Guiying Wang,
Edwin J. C. van den Oord,
Emanuel Goldman,
Chengyuan Yang,
Ning Xie,
Lan Yao,
Cong-Yi Wang,
Monica Jablonski,
Kunal Ray,
Fengxia Liu,
Wensen Pan,
Gonzalo Flores,
Lotfi Aleya,
Xia Meng,
Yan Jiao,
Minghui Li,
Yongjun Wang,
Weikuan Gu

摘要

Drug labeling and instructions provide essential information for patients regarding the usage of drugs. Instructions for the dosage of drug usage are critical for the effectiveness of the drug and the safety of patients. The dosage of many drugs varies depending on the patient's age. However, as our understanding of human biology deepens, we believe that these instructions need to be modified to incorporate different life stages. This is because human biology and metabolism differ significantly among different life stages, and their responses to drugs also vary. Additionally, the same age of different persons may fall into different life stages. Therefore, our group from multiple institutes and countries proposes a reexamination of whether incorporating life stages in all or any drug instructions will greatly enhance drug efficiency and patients' health.

Graphical Abstract

The Abstract shows that different life stages and during the periods of changes of these life stages should be considered for different drug dosages.