<p>Lignocellulose obtained from non-food crops can assist in promoting the bio-economy by being exploited as a valuable resource in biorefineries to produce diverse biomaterials, bioenergy, and biochemicals. Because of its unique and remarkable properties, it is becoming a popular biorefinery precursor for a wide range of biofuels, platform chemicals, and biomaterials. In this review, potential sources of LCBs have been discussed along with their merits and demerits in the context of biorefinery. To achieve a cost-effective route for the development of valuable end products, it is critical to select appropriate raw materials and feasible procedures. However, there are challenges to employing non-food residues in biorefinery in terms of product development, innovation, and commercialization. The complicated structural constraints and recalcitrant nature of LCBs are discussed. Thus, improved biotechnological interventions and pre-treatment strategies are highlighted to enhance such biorefineries and produce sustainable bioproducts. This review provides an overview of trends and techniques used for valorization of non-food crop-derived lignocellulose for the desired bioproducts within the green biorefinery. A structured mining of original studies was performed across databases such as Google Scholar, Scopus, PubMed, and considered 202 peer-reviewed publications published to date. This paper focuses on novel approaches to effectively transform LCBs into desired bioproducts. Apart from these, the current status, opportunities, and difficulties faced by LCBs’ biorefineries have been addressed. It provides insights into the future by critically evaluating the possibilities of this new field. A more resilient and sustainable future could be fostered by the potential to transform the bioenergy and bioproducts industry through creative research, sustainable practices, and industrial scalability.</p> Graphical Abstract <p></p>