Metabolic rewiring of microbial cell factories for improved production of succinic acid
摘要
Succinic acid (SA) is a valuable platform chemical with diverse applications. It serves as a precursor for synthesizing tetrahydrofuran, γ-butyrolactone, 1,4-butanediol, and biodegradable polymers. However, conventional chemical synthesis of SA relies solely on petroleum-derived feedstocks, raising concerns about environmental pollution and resource depletion. Microbial fermentation using renewable feedstocks offers a sustainable and environmentally friendly alternative. This review explores the current state of microbial SA production, associated bottlenecks, and recent advancements in strain improvement techniques and utilization of agro-industrial feedstocks for cost-effective bio-based SA manufacturing.