Background <p>Digital health interventions like a sleep hygiene mobile application (app) designed specifically for night shift workers, can help improve health and on-the-job safety. Successful app development should consider user experience and economic demand in addition to sleep biology. This study reports the results of a market survey which aims to assess interest in a hypothetical sleep hygiene app designed for night shift workers.</p> Methods <p><i>N</i> = 97 night shift workers, predominantly from the healthcare industry (<i>n</i> = 52), completed an anonymous online survey about their sleep habits, fatigue, technology use, perceived importance of app features, preferred pricing models, and level of comfort sharing data with employers.</p> Results <p>Respondents reported sleeping less than 7&#xa0;h on average with frequent sleep and fatigue issues in relation to their working schedules. Respondents ranked the ability of a sleep hygiene app to sync with their work schedule as the most important app feature. Slightly under half of respondents (<i>n</i> = 48) preferred a “free with ads” pricing model to one-time or recurring fees. <i>n</i> = 84 respondents were interested in using a fatigue management app; <i>n</i> = 93 would either be as interested or more interested if the app was paid for by their employer. The majority of respondents (<i>n</i> = 78) were either neutral or comfortable with sharing sleep data with their employers.</p> Conclusions <p>Night shift workers experience sleep problems and fatigue at work. Night shift workers would prefer a sleep hygiene app that takes their schedules into account and would be more likely to use an app that is either free with ads or paid for by their employer.</p>