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Background <p>Infolding is a rare but potentially life-threatening complication of self-expanding transcatheter aortic valve replacement (TAVR).</p> Case presentation <p>We describe the case of an 80-year-old man who was referred for the treatment of severe aortic stenosis complicated by heart failure. Transthoracic echocardiography revealed the following: peak velocity, 6.1&#xa0;m/s; mean pressure gradient, 102&#xa0;mmHg; and aortic valve area, 0.26&#xa0;cm<sup>2</sup>. Computed tomography (CT) showed a bicuspid aortic valve with a R-L raphe, an annular area of 529&#xa0;mm<sup>2</sup>, and a perimeter of 83.4&#xa0;mm. Considering the patient’s severe emphysema, transfemoral TAVR was performed with the patient under deep sedation. A 34-mm Evolut FX valve was implanted after predilation with a 20-mm Inoue balloon. During deployment up to the point of no recapture, hypotension occurred without improvement, and mild infolding was suspected. However, full deployment was performed, as valve optimization was considered likely to stabilize hemodynamics. Post-deployment balloon dilation was performed; however, valve under-expansion and moderate aortic regurgitation persisted. Initial hemodynamics were stabilized; however, the patient gradually developed respiratory distress. Follow-up CT confirmed substantial valve infolding. Pulmonary hypertension, alveolar hemorrhage, and disseminated intravascular coagulation developed. Surgical aortic valve replacement with a 21-mm valve was performed 15&#xa0;days post-TAVR. The explanted TAVR valve exhibited marked structural deformation. Although the patient’s circulatory status improved postoperatively, he died of respiratory failure due to pneumonia.</p> Conclusion <p>This case highlights the importance of comprehensive preoperative anatomical assessment and intraoperative decision making in high-risk patients, particularly those with bicuspid valves. Valve selection (considering the valve type and size) must be meticulously tailored to the anatomical features surrounding the annulus. In addition, upon its recognition, substantial infolding should be promptly addressed by recapturing the valve, adjusting the valve size, or redeploying the valve with additional balloon aortic valvuloplasty.</p>

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Fatal outcome after self-expanding transcatheter aortic valve replacement of the bicuspid valve due to infolding: a case report

  • 期刊论文

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  • 发表日期：

    2025年10月14日

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  • Nagi Hayashi,
  • Junji Yunoki,
  • Keijiro Shigetomi,
  • Kouhei Baba,
  • Masahide Shichijo,
  • Koki Jinnouchi,
  • Hiroyuki Morokuma,
  • Manabu Itoh,
  • Keiji Kamohara

摘要

Background

Infolding is a rare but potentially life-threatening complication of self-expanding transcatheter aortic valve replacement (TAVR).

Case presentation

We describe the case of an 80-year-old man who was referred for the treatment of severe aortic stenosis complicated by heart failure. Transthoracic echocardiography revealed the following: peak velocity, 6.1 m/s; mean pressure gradient, 102 mmHg; and aortic valve area, 0.26 cm2. Computed tomography (CT) showed a bicuspid aortic valve with a R-L raphe, an annular area of 529 mm2, and a perimeter of 83.4 mm. Considering the patient’s severe emphysema, transfemoral TAVR was performed with the patient under deep sedation. A 34-mm Evolut FX valve was implanted after predilation with a 20-mm Inoue balloon. During deployment up to the point of no recapture, hypotension occurred without improvement, and mild infolding was suspected. However, full deployment was performed, as valve optimization was considered likely to stabilize hemodynamics. Post-deployment balloon dilation was performed; however, valve under-expansion and moderate aortic regurgitation persisted. Initial hemodynamics were stabilized; however, the patient gradually developed respiratory distress. Follow-up CT confirmed substantial valve infolding. Pulmonary hypertension, alveolar hemorrhage, and disseminated intravascular coagulation developed. Surgical aortic valve replacement with a 21-mm valve was performed 15 days post-TAVR. The explanted TAVR valve exhibited marked structural deformation. Although the patient’s circulatory status improved postoperatively, he died of respiratory failure due to pneumonia.

Conclusion

This case highlights the importance of comprehensive preoperative anatomical assessment and intraoperative decision making in high-risk patients, particularly those with bicuspid valves. Valve selection (considering the valve type and size) must be meticulously tailored to the anatomical features surrounding the annulus. In addition, upon its recognition, substantial infolding should be promptly addressed by recapturing the valve, adjusting the valve size, or redeploying the valve with additional balloon aortic valvuloplasty.