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Objective <p>To identify potential differences in lung microbiota according to clinical severity, age, and gender in pneumonia patients compared to controls.</p> Design <p>Pilot study.</p> Setting <p>Single center (Azienda Ospedaliera Universitaria Dulbecco, Catanzaro, Italy).</p> Patients <p>Thirty-three individuals—11 ICU patients requiring invasive mechanical ventilation, 11 non-ICU patients, and 11 cadaver controls without lung disease.</p> Interventions <p>Bronchoalveolar lavage sample collection and analysis via microbiological cultures and metagenomic sequencing.</p> Measurements and main results <p>Bacteroidota and Verrucomicrobiota phyla were more abundant in older (≥65&#xa0;years) ICU and non-ICU patients versus controls. <i>Massilia timonae</i> showed a significantly lower relative abundance at the group level in cases compared to controls, potentially increasing infection susceptibility. Higher microbiota diversity was observed in older patients.</p> Conclusions <p>Alterations in lung microbiota composition were observed in pneumonia patients, with differences that appeared more evident in older patients. Microbiota phenotyping may offer novel insights into pneumonia pathophysiology and pulmonary dysbiosis.</p>

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Characterization of lung microbiota in pneumonia: a pilot study in ICU and non-ICU patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月24日

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  • Andrea Bruni,
  • Eugenio Garofalo,
  • Alessandro Russo,
  • Corrado Pelaia,
  • Federico Longhini,
  • Elisa Bona,
  • Isabella Aquila,
  • Paolo Navalesi,
  • Annalisa Boscolo,
  • Alice Caramaschi,
  • Chiara Bazzano,
  • Nadia Massa,
  • Denise Battaglini,
  • Zaninni Caroleo,
  • Giuseppe Neri,
  • Matteo Sacco,
  • Eugenio Biamonte,
  • Francesca Serapide,
  • Saverio Gualtieri,
  • Cosimo Stefano,
  • Giuseppina Marrazzo,
  • Arianna Peralta

摘要

Objective

To identify potential differences in lung microbiota according to clinical severity, age, and gender in pneumonia patients compared to controls.

Design

Pilot study.

Setting

Single center (Azienda Ospedaliera Universitaria Dulbecco, Catanzaro, Italy).

Patients

Thirty-three individuals—11 ICU patients requiring invasive mechanical ventilation, 11 non-ICU patients, and 11 cadaver controls without lung disease.

Interventions

Bronchoalveolar lavage sample collection and analysis via microbiological cultures and metagenomic sequencing.

Measurements and main results

Bacteroidota and Verrucomicrobiota phyla were more abundant in older (≥65 years) ICU and non-ICU patients versus controls. Massilia timonae showed a significantly lower relative abundance at the group level in cases compared to controls, potentially increasing infection susceptibility. Higher microbiota diversity was observed in older patients.

Conclusions

Alterations in lung microbiota composition were observed in pneumonia patients, with differences that appeared more evident in older patients. Microbiota phenotyping may offer novel insights into pneumonia pathophysiology and pulmonary dysbiosis.