<p>This paper briefly introduces the research status of mineral processing and mineral processing agents and summarizes the mineral processing technical difficulties of copper-nickel sulfide ore into five points: the difficulties in dissociation of copper-nickel mineral monomer, magnesium-containing silicate minerals have a great influence on flotation, the separation process of copper and nickel easily leads to the mixing of nickel and copper, effects of certain ions on flotation, and the recovery of associated precious metal elements. The key technical problems for beneficiation of copper-nickel sulfide ore are discussed and pointed out that the embedding particle size, embedding relationship, and gangue mineral type determine the formulation of the mineral processing process. Based on process mineralogy research, developing a scientific and reasonable comprehensive mineral processing process is the key to doing a good job of copper-nickel processing technology indexes, comprehensive recovery of various valuable metals, and improved economic benefits.</p>