Background/aims <p>This study was conducted to identify the mortality risk factors in patients hospitalized due to pneumonia and to evaluate the prognostic power of clinical and biochemical markers. Pneumonia is a significant cause of morbidity and mortality worldwide. The clinical condition of patients is influenced by various factors such as age, comorbidities, performance score, and biochemical markers.</p> Methods <p>The study was designed retrospectively, analyzing the medical records of 233 pneumonia patients. Clinical (age, gender, length of hospital stay, comorbidities, etc.) and biochemical (CRP, LDH, procalcitonin, pH, etc.) data were assessed using statistical methods such as logistic regression and ROC analysis.</p> Results <p>Statistical analyses revealed that high CRP and procalcitonin levels, as well as low serum albumin and pH levels, were significantly associated with mortality. The ECOG performance score and the need for ventilation were correlated with a poor prognosis. Age and comorbidities (DM, hypertension, etc.) showed a weaker-than-expected relationship with mortality.</p> Conclusion <p>Evaluating the markers influencing mortality in pneumonia patients is important for improving clinical management and developing more effective treatment strategies. Biochemical parameters such as CRP, procalcitonin, and pH, along with the ECOG score, are crucial in pneumonia prognosis. Further research with larger sample sizes is required to validate these findings.</p>